IDEAS home Printed from https://ideas.repec.org/a/taf/mpopst/v18y2011i2p55-86.html
   My bibliography  Save this article

Immune Response and Imperfect Vaccine in Malaria Dynamics

Author

Listed:
  • ASHRAFI NIGER
  • ABBA GUMEL

Abstract

The immune response to malaria and the effects of an imperfect vaccine for this disease are modelled incorporating an n stage parasite life cycle, immune cells, and antibodies. A globally asymptotically stable parasite-free equilibrium occurs when the associated reproduction number is less than unity. An imperfect malaria vaccine that reduces the number of merozoites released per bursting infected red blood cell (IRBC) and that boosts immune response can reduce the concentration of IRBCs in vivo. Numerical simulations show that a vaccine efficacy of at least 87% is necessary to eliminate IRBC in vivo. The concentration of IRBCs varies with the capacity of the vaccine to modify the total number of merozoites released per bursting IRBC.

Suggested Citation

  • Ashrafi Niger & Abba Gumel, 2011. "Immune Response and Imperfect Vaccine in Malaria Dynamics," Mathematical Population Studies, Taylor & Francis Journals, vol. 18(2), pages 55-86.
  • Handle: RePEc:taf:mpopst:v:18:y:2011:i:2:p:55-86
    DOI: 10.1080/08898480.2011.564560
    as

    Download full text from publisher

    File URL: http://www.tandfonline.com/doi/abs/10.1080/08898480.2011.564560
    Download Restriction: Access to full text is restricted to subscribers.

    File URL: https://libkey.io/10.1080/08898480.2011.564560?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Forouzannia, Farinaz & Gumel, A., 2015. "Dynamics of an age-structured two-strain model for malaria transmission," Applied Mathematics and Computation, Elsevier, vol. 250(C), pages 860-886.
    2. Deka, Aniruddha & Bhattacharyya, Samit, 2022. "The effect of human vaccination behaviour on strain competition in an infectious disease: An imitation dynamic approach," Theoretical Population Biology, Elsevier, vol. 143(C), pages 62-76.
    3. Ahmed Elaiw & Afnan Al Agha, 2020. "Global Analysis of a Reaction-Diffusion Within-Host Malaria Infection Model with Adaptive Immune Response," Mathematics, MDPI, vol. 8(4), pages 1-32, April.
    4. Mittal, R.C. & Goel, Rohit & Ahlawat, Neha, 2021. "An Efficient Numerical Simulation of a Reaction-Diffusion Malaria Infection Model using B-splines Collocation," Chaos, Solitons & Fractals, Elsevier, vol. 143(C).
    5. Raouf Boucekkine, 2012. "Epidemics From the Economic Theory Viewpoint," Mathematical Population Studies, Taylor & Francis Journals, vol. 19(1), pages 1-3, January.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:taf:mpopst:v:18:y:2011:i:2:p:55-86. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Chris Longhurst (email available below). General contact details of provider: http://www.tandfonline.com/GMPS20 .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.