IDEAS home Printed from https://ideas.repec.org/a/taf/lstaxx/v51y2022i8p2343-2356.html
   My bibliography  Save this article

Weighted step-down confidence procedures with applications to gene expression data

Author

Listed:
  • Yang Yu
  • John T. Chen
  • Arthur B. Yeh

Abstract

It is critical to incorporate additional information of parameters into the simultaneous estimation process. In this paper, we propose a new confidence method that utilizes the information on parameter priority and keeps the elegance and simplicity of Holm’s weighted testing procedure. The new method is grounded on the method of random partitions, in conjunction with probability inequalities, to ensure the control of the simultaneous confidence level. Simulation studies show significant power improvements for appropriately assigned weights. The new confidence method casts new lights on differential gene expression among mutant genes that are associated with BRCA1 and BRCA2 proteins in the DNA repair process.

Suggested Citation

  • Yang Yu & John T. Chen & Arthur B. Yeh, 2022. "Weighted step-down confidence procedures with applications to gene expression data," Communications in Statistics - Theory and Methods, Taylor & Francis Journals, vol. 51(8), pages 2343-2356, April.
    • Handle: RePEc:taf:lstaxx:v:51:y:2022:i:8:p:2343-2356
    DOI: 10.1080/03610926.2020.1772983
    as

    Download full text from publisher

    File URL: http://hdl.handle.net/10.1080/03610926.2020.1772983
    Download Restriction: Access to full text is restricted to subscribers.
    File URL: https://libkey.io/10.1080/03610926.2020.1772983?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Yehan Ma & Arthur B. Yeh & John T. Chen, 2023. "Simultaneous Confidence Regions and Weighted Hypotheses on Parameter Arrays," Methodology and Computing in Applied Probability, Springer, vol. 25(2), pages 1-18, June.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:taf:lstaxx:v:51:y:2022:i:8:p:2343-2356. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Chris Longhurst (email available below). General contact details of provider: http://www.tandfonline.com/lsta .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.