IDEAS home Printed from https://ideas.repec.org/a/taf/japsta/v31y2004i10p1241-1248.html
   My bibliography  Save this article

A Shape-based Glaucoma Index for Tomographic Images

Author

Listed:
  • Gordana Derado
  • Kanti Mardia
  • Vic Patrangenaru
  • Hilary Thompson

Abstract

We examine the use of Confocal Laser Tomographic images for detecting glaucoma. From the clinical aspect, the optic nerve head's (ONH) area contains all the relevant information on glaucoma. The shape of ONH is approximately a skewed cup. We summarize its shape by three biological landmarks on the neural-rim and the fourth landmark as the point of the maximum depth, which is approximately the point where the optic nerve enters this eye cup. These four landmarks are extracted from the images related to some Rhesus monkeys before and after inducing glaucoma. Previous analysis on Bookstein shape coordinates of these four landmarks revealed only marginally significant findings. From clinical experience, it is believed that the ratio depth to diameter of the eye cup provides a useful measure of the shape change. We consider the bootstrap distribution of this normalized 'depth' (G) and give evidence that it provides an appropriate measure of the shape change. This measure G is labelled as the glaucoma index. Further experiments are in progress to validate its use for glaucoma in humans.

Suggested Citation

  • Gordana Derado & Kanti Mardia & Vic Patrangenaru & Hilary Thompson, 2004. "A Shape-based Glaucoma Index for Tomographic Images," Journal of Applied Statistics, Taylor & Francis Journals, vol. 31(10), pages 1241-1248.
    • Handle: RePEc:taf:japsta:v:31:y:2004:i:10:p:1241-1248
    DOI: 10.1080/0266476042000285486
    as

    Download full text from publisher

    File URL: http://www.tandfonline.com/doi/abs/10.1080/0266476042000285486
    Download Restriction: Access to full text is restricted to subscribers.
    File URL: https://libkey.io/10.1080/0266476042000285486?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Crane, M. & Patrangenaru, V., 2011. "Random change on a Lie group and mean glaucomatous projective shape change detection from stereo pair images," Journal of Multivariate Analysis, Elsevier, vol. 102(2), pages 225-237, February.
    2. Bandulasiri, Ananda & Bhattacharya, Rabi N. & Patrangenaru, Vic, 2009. "Nonparametric inference for extrinsic means on size-and-(reflection)-shape manifolds with applications in medical imaging," Journal of Multivariate Analysis, Elsevier, vol. 100(9), pages 1867-1882, October.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:taf:japsta:v:31:y:2004:i:10:p:1241-1248. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Chris Longhurst (email available below). General contact details of provider: http://www.tandfonline.com/CJAS20 .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.