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Covariate-adjusted linear mixed effects model with an application to longitudinal data

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  • Danh Nguyen
  • Damla şentürk
  • Raymond Carroll

Abstract

Linear mixed effects (LME) models are useful for longitudinal data/repeated measurements. We propose a new class of covariate-adjusted LME models for longitudinal data that nonparametrically adjusts for a normalising covariate. The proposed approach involves fitting a parametric LME model to the data after adjusting for the nonparametric effects of a baseline confounding covariate. In particular, the effect of the observable covariate on the response and predictors of the LME model is modelled nonparametrically via smooth unknown functions. In addition to covariate-adjusted estimation of fixed/population parameters and random effects, an estimation procedure for the variance components is also developed. Numerical properties of the proposed estimators are investigated with simulation studies. The consistency and convergence rates of the proposed estimators are also established. An application to a longitudinal data set on calcium absorption, accounting for baseline distortion from body mass index, illustrates the proposed methodology.

Suggested Citation

  • Danh Nguyen & Damla şentürk & Raymond Carroll, 2008. "Covariate-adjusted linear mixed effects model with an application to longitudinal data," Journal of Nonparametric Statistics, Taylor & Francis Journals, vol. 20(6), pages 459-481.
    • Handle: RePEc:taf:gnstxx:v:20:y:2008:i:6:p:459-481
    DOI: 10.1080/10485250802226435
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    References listed on IDEAS

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    1. Stephen J. Iturria & Raymond J. Carroll & David Firth, 1999. "Polynomial Regression and Estimating Functions in the Presence of Multiplicative Measurement Error," Journal of the Royal Statistical Society Series B, Royal Statistical Society, vol. 61(3), pages 547-561.
    2. Hulin Wu & Hua Liang, 2004. "Backfitting Random Varying‐Coefficient Models with Time‐Dependent Smoothing Covariates," Scandinavian Journal of Statistics, Danish Society for Theoretical Statistics;Finnish Statistical Society;Norwegian Statistical Association;Swedish Statistical Association, vol. 31(1), pages 3-19, March.
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    Cited by:

    1. Jun Zhang & Junpeng Zhu & Yan Zhou & Xia Cui & Tao Lu, 2020. "Multiplicative regression models with distortion measurement errors," Statistical Papers, Springer, vol. 61(5), pages 2031-2057, October.
    2. Jun Zhang & Yiping Yang & Gaorong Li, 2020. "Logarithmic calibration for multiplicative distortion measurement errors regression models," Statistica Neerlandica, Netherlands Society for Statistics and Operations Research, vol. 74(4), pages 462-488, November.
    3. Jun Zhang & Nanguang Zhou & Zipeng Sun & Gaorong Li & Zhenghong Wei, 2016. "Statistical inference on restricted partial linear regression models with partial distortion measurement errors," Statistica Neerlandica, Netherlands Society for Statistics and Operations Research, vol. 70(4), pages 304-331, November.
    4. Zhang, Jun & Feng, Zhenghui & Zhou, Bu, 2014. "A revisit to correlation analysis for distortion measurement error data," Journal of Multivariate Analysis, Elsevier, vol. 124(C), pages 116-129.

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