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Radiation-induced changes in load-sharing and structure-function behavior in murine lumbar vertebrae

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  • Tongge Wu
  • Noah B. Bonnheim
  • Megan M. Pendleton
  • Shannon R. Emerzian
  • Tony M. Keaveny

Abstract

In this study, we used micro-CT-based finite element analysis to investigate the biomechanical effects of radiation on the microstructure and mechanical function of murine lumbar vertebrae. Specifically, we evaluated vertebral microstructure, whole-bone stiffness, and cortical-trabecular load sharing in the L5 vertebral body of mice exposed to ionizing radiation 11 days post exposure (5 Gy total dose; n = 13) and controls (n = 14). Our findings revealed the irradiated group exhibited reduced trabecular bone volume and microstructure (p

Suggested Citation

  • Tongge Wu & Noah B. Bonnheim & Megan M. Pendleton & Shannon R. Emerzian & Tony M. Keaveny, 2024. "Radiation-induced changes in load-sharing and structure-function behavior in murine lumbar vertebrae," Computer Methods in Biomechanics and Biomedical Engineering, Taylor & Francis Journals, vol. 27(10), pages 1278-1286, July.
    • Handle: RePEc:taf:gcmbxx:v:27:y:2024:i:10:p:1278-1286
    DOI: 10.1080/10255842.2023.2239415
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