IDEAS home Printed from https://ideas.repec.org/a/taf/gcmbxx/v24y2021i6p653-662.html
   My bibliography  Save this article

Mathematical modeling of the Fontan blood circulation supported with pediatric ventricular assist device

Author

Listed:
  • Ekaterina Rubtsova
  • Aleksandr Markov
  • Sergey Selishchev
  • Jamshid H. Karimov
  • Dmitry Telyshev

Abstract

The decompensated univentricular circulation is identified as one of the most challenging conditions and the application of the mechanical circulatory support (MCS) devices is proposed as therapeutic option for Fontan failure. Modelling methodologies are reported to identify the optimized types, extent and duration of required hemodynamic support using MCS. The specific parameters of device-body interaction during support of failing Fontan circulation within the design points of dedicated pediatric ventricular assist devices has not been previously defined. In this work, we introduce a mathematical model developed to simulate the interaction between the Fontan single-ventricular circulation and a constant-flow pediatric ventricular assist device (VAD) Sputnik. The interaction is studied at a pump rotor speed of 5000–9000 rpm. This simulation demonstrates that the pump replacing pulmonary ventricle of the heart creates necessary pressure differential between the systemic veins (7 mmHg) and the pulmonary artery (17.3 mmHg). Moreover, it increases the venous return that, according to the Frank-Starling mechanism, increases the stroke volume up to 32 ml/bpm (26 ml/bpm - without using a pump). For the first time, a simulation for the pediatric VAD Sputnik has been carried out. The simulation results confirm pediatric VAD Sputnik can be a possible tool to normalize the Fontan circulation in pediatric patients.

Suggested Citation

  • Ekaterina Rubtsova & Aleksandr Markov & Sergey Selishchev & Jamshid H. Karimov & Dmitry Telyshev, 2021. "Mathematical modeling of the Fontan blood circulation supported with pediatric ventricular assist device," Computer Methods in Biomechanics and Biomedical Engineering, Taylor & Francis Journals, vol. 24(6), pages 653-662, April.
    • Handle: RePEc:taf:gcmbxx:v:24:y:2021:i:6:p:653-662
    DOI: 10.1080/10255842.2020.1843640
    as

    Download full text from publisher

    File URL: http://hdl.handle.net/10.1080/10255842.2020.1843640
    Download Restriction: Access to full text is restricted to subscribers.
    File URL: https://libkey.io/10.1080/10255842.2020.1843640?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:taf:gcmbxx:v:24:y:2021:i:6:p:653-662. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Chris Longhurst (email available below). General contact details of provider: http://www.tandfonline.com/gcmb .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.