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Beyond apical ballooning: computational modelling reveals morphological features of Takotsubo cardiomyopathy

Author

Listed:
  • Giulia Pontecorboli
  • Giovanni Biglino
  • Elena Giulia Milano
  • Froso Sophocleous
  • Benedetta Biffi
  • Amardeep Ghosh Dastidar
  • Silvia Schievano
  • Carlo Di Mario
  • Chiara Bucciarelli-Ducci

Abstract

Takotsubo cardiomyopathy (TCM) is characterized by transient myocardial dysfunction, typically at the left ventricular (LV) apex. Its pathophysiology and recovery mechanisms remain unknown. We investigated LV morphology and deformation in n = 28 TCM patients. Patients with MRI within 5 days from admission (“early TCM”) showed reduced LVEF and higher ventricular volumes, but no differences in ECG, global strains or myocardial oedema. Statistical shape modelling described LV size (Mode 1), apical sphericity (Mode 2) and height (Mode 3). Significant differences in Mode 1 suggest that “early TCM” LV remodeling is mainly influenced by a change in ventricular size rather than apical sphericity.

Suggested Citation

  • Giulia Pontecorboli & Giovanni Biglino & Elena Giulia Milano & Froso Sophocleous & Benedetta Biffi & Amardeep Ghosh Dastidar & Silvia Schievano & Carlo Di Mario & Chiara Bucciarelli-Ducci, 2019. "Beyond apical ballooning: computational modelling reveals morphological features of Takotsubo cardiomyopathy," Computer Methods in Biomechanics and Biomedical Engineering, Taylor & Francis Journals, vol. 22(14), pages 1103-1106, October.
    • Handle: RePEc:taf:gcmbxx:v:22:y:2019:i:14:p:1103-1106
    DOI: 10.1080/10255842.2019.1632836
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