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Modeling the effect of blood vessel bifurcation ratio on occlusive thrombus formation

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  • Hari Hara Sudhan Lakshmanan
  • Joseph J. Shatzel
  • Sven R. Olson
  • Owen J.T. McCarty
  • Jeevan Maddala

Abstract

Vascular geometry is a major determinant of the hemodynamics that promote or prevent unnecessary vessel occlusion from thrombus formation. Bifurcations in the vascular geometry are repeating structures that introduce flow separation between parent and daughter vessels. We modelled the blood flow and shear rate in a bifurcation during thrombus formation and show that blood vessel bifurcation ratios determine the maximum shear rate on the surface of a growing thrombus. We built an analytical model that may aid in predicting microvascular bifurcation ratios that are prone to occlusive thrombus formation. We also observed that bifurcation ratios that adhere to Murray’s law of bifurcations may be protected from occlusive thrombus formation. These results may be useful in the rational design of diagnostic microfluidic devices and microfluidic blood oxygenators.

Suggested Citation

  • Hari Hara Sudhan Lakshmanan & Joseph J. Shatzel & Sven R. Olson & Owen J.T. McCarty & Jeevan Maddala, 2019. "Modeling the effect of blood vessel bifurcation ratio on occlusive thrombus formation," Computer Methods in Biomechanics and Biomedical Engineering, Taylor & Francis Journals, vol. 22(11), pages 972-980, August.
    • Handle: RePEc:taf:gcmbxx:v:22:y:2019:i:11:p:972-980
    DOI: 10.1080/10255842.2019.1610744
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    Cited by:

    1. Anastasia Mozokhina & Anass Bouchnita & Vitaly Volpert, 2021. "Blood Clotting Decreases Pulmonary Circulation during the Coronavirus Disease," Mathematics, MDPI, vol. 9(19), pages 1-19, September.

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