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Estimation of the physiological mechanical conditioning in vascular tissue engineering by a predictive fluid-structure interaction approach

Author

Listed:
  • Claudia Tresoldi
  • Elena Bianchi
  • Alessandro Filippo Pellegata
  • Gabriele Dubini
  • Sara Mantero

Abstract

The in vitro replication of physiological mechanical conditioning through bioreactors plays a crucial role in the development of functional Small-Caliber Tissue-Engineered Blood Vessels. An in silico scaffold-specific model under pulsatile perfusion provided by a bioreactor was implemented using a fluid-structure interaction (FSI) approach for viscoelastic tubular scaffolds (e.g. decellularized swine arteries, DSA). Results of working pressures, circumferential deformations, and wall shear stress on DSA fell within the desired physiological range and indicated the ability of this model to correctly predict the mechanical conditioning acting on the cells-scaffold system. Consequently, the FSI model allowed us to a priori define the stimulation pattern, driving in vitro physiological maturation of scaffolds, especially with viscoelastic properties.

Suggested Citation

  • Claudia Tresoldi & Elena Bianchi & Alessandro Filippo Pellegata & Gabriele Dubini & Sara Mantero, 2017. "Estimation of the physiological mechanical conditioning in vascular tissue engineering by a predictive fluid-structure interaction approach," Computer Methods in Biomechanics and Biomedical Engineering, Taylor & Francis Journals, vol. 20(10), pages 1077-1088, July.
    • Handle: RePEc:taf:gcmbxx:v:20:y:2017:i:10:p:1077-1088
    DOI: 10.1080/10255842.2017.1332192
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