IDEAS home Printed from https://ideas.repec.org/a/taf/gcmbxx/v18y2015i6p628-634.html
   My bibliography  Save this article

Determining possible thrombus sites in an extracorporeal device, using computational fluid dynamics-derived relative residence time

Author

Listed:
  • N. Gorring
  • L. Kark
  • A. Simmons
  • T. Barber

Abstract

The prediction of conditions that may result in thrombus formation is a useful application of computational fluid dynamics. A number of techniques exist, based on the consideration of wall shear stress and regions of low blood flow; however, no clear guideline exists for the best practice of their use. In this paper, the sensitivity of each parameter and the specific mechanical forces are explained, before the optimal indicator of thrombosis risk is outlined. An extracorporeal access device cavity provides a suitable geometry to test the methodology. The recommended method for thrombus prediction considers areas with a calculated residence time (RT) and shear strain rate (SSR) thresholds, here set to RT>1 and SSR < 10 s− 1. Evidence of thrombosis was found for physiological waveforms with an absence of reverse flow, which is expected to ‘wash out’ the cavity. The predicted thrombosis sites compare well with evidence collected from explanted devices.

Suggested Citation

  • N. Gorring & L. Kark & A. Simmons & T. Barber, 2015. "Determining possible thrombus sites in an extracorporeal device, using computational fluid dynamics-derived relative residence time," Computer Methods in Biomechanics and Biomedical Engineering, Taylor & Francis Journals, vol. 18(6), pages 628-634, April.
    • Handle: RePEc:taf:gcmbxx:v:18:y:2015:i:6:p:628-634
    DOI: 10.1080/10255842.2013.826655
    as

    Download full text from publisher

    File URL: http://hdl.handle.net/10.1080/10255842.2013.826655
    Download Restriction: Access to full text is restricted to subscribers.
    File URL: https://libkey.io/10.1080/10255842.2013.826655?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:taf:gcmbxx:v:18:y:2015:i:6:p:628-634. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Chris Longhurst (email available below). General contact details of provider: http://www.tandfonline.com/gcmb .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.