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A semi-automated method for patient-specific computational flow modelling of left ventricles

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  • Vinh-Tan Nguyen
  • Chong Jia Loon
  • Hoang Huy Nguyen
  • Zhong Liang
  • Hwa Liang Leo

Abstract

Patient-specific computational fluid dynamics (CFD) modelling of the left ventricle (LV) is a promising technique for the visualisation of ventricular flow patterns throughout a cardiac cycle. While significant progress has been made in improving the physiological quality of such simulations, the methodologies involved for several key steps remain significantly operator-dependent to this day. This dependency limits both the efficiency of the process as well as the consistency of CFD results due to the labour-intensive nature of current methods as well as operator introduced uncertainties in the modelling process. In order to mitigate this dependency, we propose a semi-automated method for patient-specific computational flow modelling of the LV. Using magnetic resonance imaging derived coarse geometry data of a patient's LV endocardium shape throughout a cardiac cycle, we then proceed to refine the geometry to eliminate rough edges before reconstructing meshes for all time frames and finally numerically solving for the intra-ventricular flow. Using a sample of patient-specific volunteer data, we demonstrate that our semi-automated, minimal operator involvement approach is capable of yielding CFD results of the LV that are comparable to other clinically validated LV flow models in the literature.

Suggested Citation

  • Vinh-Tan Nguyen & Chong Jia Loon & Hoang Huy Nguyen & Zhong Liang & Hwa Liang Leo, 2015. "A semi-automated method for patient-specific computational flow modelling of left ventricles," Computer Methods in Biomechanics and Biomedical Engineering, Taylor & Francis Journals, vol. 18(4), pages 401-413, March.
    • Handle: RePEc:taf:gcmbxx:v:18:y:2015:i:4:p:401-413
    DOI: 10.1080/10255842.2013.803534
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    References listed on IDEAS

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    1. S.S. Khalafvand & E.Y.K. Ng & L. Zhong, 2011. "CFD simulation of flow through heart: a perspective review," Computer Methods in Biomechanics and Biomedical Engineering, Taylor & Francis Journals, vol. 14(01), pages 113-132.
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