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Mechanical evaluation of a tissue-engineered zone of calcification in a bone–hydrogel osteochondral construct

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  • Jérôme Hollenstein
  • Alexandre Terrier
  • Esther Cory
  • Albert C. Chen
  • Robert L. Sah
  • Dominique P. Pioletti

Abstract

The objective of this study was to test the hypothesis that mechanical properties of artificial osteochondral constructs can be improved by a tissue-engineered zone of calcification (teZCC) at the bone–hydrogel interface. Experimental push-off tests were performed on osteochondral constructs with or without a teZCC. In parallel, a numerical model of the osteochondral defect treatment was developed and validated against experimental results. Experimental results showed that the shear strength at the bone–hydrogel interface increased by 100% with the teZCC. Numerical predictions of the osteochondral defect treatment showed that the shear stress at the bone–hydrogel interface was reduced with the teZCC. We conclude that a teZCC in osteochondral constructs can provide two improvements. First, it increases the strength of the bone–hydrogel interface and second, it reduces the stress at this interface.

Suggested Citation

  • Jérôme Hollenstein & Alexandre Terrier & Esther Cory & Albert C. Chen & Robert L. Sah & Dominique P. Pioletti, 2015. "Mechanical evaluation of a tissue-engineered zone of calcification in a bone–hydrogel osteochondral construct," Computer Methods in Biomechanics and Biomedical Engineering, Taylor & Francis Journals, vol. 18(3), pages 332-337, February.
    • Handle: RePEc:taf:gcmbxx:v:18:y:2015:i:3:p:332-337
    DOI: 10.1080/10255842.2013.794898
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    1. Ali Vahdati & Diane Wagner, 2012. "Finite element study of a tissue-engineered cartilage transplant in human tibiofemoral joint," Computer Methods in Biomechanics and Biomedical Engineering, Taylor & Francis Journals, vol. 15(11), pages 1211-1221.
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