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Micro-structurally detailed model of a therapeutic hydrogel injectate in a rat biventricular cardiac geometry for computational simulations

Author

Listed:
  • Mazin S. Sirry
  • Neil H. Davies
  • Karen Kadner
  • Laura Dubuis
  • Muhammad G. Saleh
  • Ernesta M. Meintjes
  • Bruce S. Spottiswoode
  • Peter Zilla
  • Thomas Franz

Abstract

Biomaterial injection-based therapies have showed cautious success in restoration of cardiac function and prevention of adverse remodelling into heart failure after myocardial infarction (MI). However, the underlying mechanisms are not well understood. Computational studies utilised simplified representations of the therapeutic myocardial injectates. Wistar rats underwent experimental infarction followed by immediate injection of polyethylene glycol hydrogel in the infarct region. Hearts were explanted, cryo-sectioned and the region with the injectate histologically analysed. Histological micrographs were used to reconstruct the dispersed hydrogel injectate. Cardiac magnetic resonance imaging data from a healthy rat were used to obtain an end-diastolic biventricular geometry which was subsequently adjusted and combined with the injectate model. The computational geometry of the injectate exhibited microscopic structural details found the in situ. The combination of injectate and cardiac geometry provides realistic geometries for multiscale computational studies of intra-myocardial injectate therapies for the rat model that has been widely used for MI research.

Suggested Citation

  • Mazin S. Sirry & Neil H. Davies & Karen Kadner & Laura Dubuis & Muhammad G. Saleh & Ernesta M. Meintjes & Bruce S. Spottiswoode & Peter Zilla & Thomas Franz, 2015. "Micro-structurally detailed model of a therapeutic hydrogel injectate in a rat biventricular cardiac geometry for computational simulations," Computer Methods in Biomechanics and Biomedical Engineering, Taylor & Francis Journals, vol. 18(3), pages 325-331, February.
    • Handle: RePEc:taf:gcmbxx:v:18:y:2015:i:3:p:325-331
    DOI: 10.1080/10255842.2013.793765
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    References listed on IDEAS

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    1. Jeroen Kortsmit & Neil H. Davies & Renee Miller & Jesse R. Macadangdang & Peter Zilla & Thomas Franz, 2013. "The effect of hydrogel injection on cardiac function and myocardial mechanics in a computational post-infarction model," Computer Methods in Biomechanics and Biomedical Engineering, Taylor & Francis Journals, vol. 16(11), pages 1185-1195, November.
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