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A diffusion tensor-based finite element model of microdialysis in the deep brain

Author

Listed:
  • Elin Diczfalusy
  • Mats Andersson
  • Karin Wårdell

Abstract

Microdialysis of the basal ganglia was recently used to study neurotransmitter levels in relation to deep brain stimulation. In order to estimate the anatomical origin of the obtained data, the maximum tissue volume of influence (TVImax) for a microdialysis catheter was simulated using the finite element method. This study investigates the impact of brain heterogeneity and anisotropy on the TVImax using diffusion tensor imaging (DTI) to create a second-order tensor model of the basal ganglia. Descriptive statistics showed that the maximum migration distance for neurotransmitters varied by up to 55% (n = 98,444) for DTI-based simulations compared with an isotropic reference model, and the anisotropy differed between different targets in accordance with theory. The size of the TVImax was relevant in relation to the size of the anatomical structures of interest, and local tissue properties should be accounted for when relating microdialysis data to their anatomical targets.

Suggested Citation

  • Elin Diczfalusy & Mats Andersson & Karin Wårdell, 2015. "A diffusion tensor-based finite element model of microdialysis in the deep brain," Computer Methods in Biomechanics and Biomedical Engineering, Taylor & Francis Journals, vol. 18(2), pages 201-212, January.
    • Handle: RePEc:taf:gcmbxx:v:18:y:2015:i:2:p:201-212
    DOI: 10.1080/10255842.2013.789103
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