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Translation of biomechanical concepts in bone tissue engineering: from animal study to revision knee arthroplasty

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  • A. Roshan-Ghias
  • A. Terrier
  • B.M. Jolles
  • D.P. Pioletti

Abstract

Bone defects in revision knee arthroplasty are often located in load-bearing regions. The goal of this study was to determine whether a physiologic load could be used as an in situ osteogenic signal to the scaffolds filling the bone defects. In order to answer this question, we proposed a novel translation procedure having four steps: (1) determining the mechanical stimulus using finite element method, (2) designing an animal study to measure bone formation spatially and temporally using micro-CT imaging in the scaffold subjected to the estimated mechanical stimulus, (3) identifying bone formation parameters for the loaded and non-loaded cases appearing in a recently developed mathematical model for bone formation in the scaffold and (4) estimating the stiffness and the bone formation in the bone-scaffold construct. With this procedure, we estimated that after 3 years mechanical stimulation increases the bone volume fraction and the stiffness of scaffold by 1.5- and 2.7-fold, respectively, compared to a non-loaded situation.

Suggested Citation

  • A. Roshan-Ghias & A. Terrier & B.M. Jolles & D.P. Pioletti, 2014. "Translation of biomechanical concepts in bone tissue engineering: from animal study to revision knee arthroplasty," Computer Methods in Biomechanics and Biomedical Engineering, Taylor & Francis Journals, vol. 17(8), pages 845-852, June.
    • Handle: RePEc:taf:gcmbxx:v:17:y:2014:i:8:p:845-852
    DOI: 10.1080/10255842.2012.719607
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    References listed on IDEAS

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    1. Alexandre Terrier & Marjan Sedighi-Gilani & Alireza Roshan Ghias & Line Aschwanden & Dominique P. Pioletti, 2009. "Biomechanical evaluation of porous biodegradable scaffolds for revision knee arthroplasty," Computer Methods in Biomechanics and Biomedical Engineering, Taylor & Francis Journals, vol. 12(3), pages 333-339.
    2. Dominique P. Pioletti, 2010. "Biomechanics in bone tissue engineering," Computer Methods in Biomechanics and Biomedical Engineering, Taylor & Francis Journals, vol. 13(6), pages 837-846.
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