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A two population model of prion transport through a tunnelling nanotube

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  • I.A. Kuznetsov
  • A.V. Kuznetsov

Abstract

This article develops a two prion population model that simulates prion trafficking between an infected dendritic cell and a neuron. The situation when the two cells are connected by a tunnelling nanotube (TNT) is simulated. Two mechanisms of prion transport are considered: lateral diffusion in the TNT membrane and active actin-dependent transport inside endocytic vesicles that are propelled by myosin Va molecular motors. Analytical solutions describing prion concentrations and fluxes are obtained. Numerical results are compared with those predicted by a single prion population model that relies on a single reaction–diffusion equation and accounts for the two modes of prion transport in an effective way.

Suggested Citation

  • I.A. Kuznetsov & A.V. Kuznetsov, 2014. "A two population model of prion transport through a tunnelling nanotube," Computer Methods in Biomechanics and Biomedical Engineering, Taylor & Francis Journals, vol. 17(15), pages 1705-1715, November.
    • Handle: RePEc:taf:gcmbxx:v:17:y:2014:i:15:p:1705-1715
    DOI: 10.1080/10255842.2013.763938
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    1. Roberta Kwok, 2011. "Cell biology: The new cell anatomy," Nature, Nature, vol. 480(7375), pages 26-28, December.
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