IDEAS home Printed from https://ideas.repec.org/a/taf/gcmbxx/v16y2013i7p802-805.html
   My bibliography  Save this article

Towards real-time simulation of cardiac electrophysiology in a human heart at high resolution

Author

Listed:
  • David F. Richards
  • James N. Glosli
  • Erik W. Draeger
  • Arthur A. Mirin
  • Bor Chan
  • Jean-luc Fattebert
  • William D. Krauss
  • Tomas Oppelstrup
  • Chris J. Butler
  • John A. Gunnels
  • Viatcheslav Gurev
  • Changhoan Kim
  • John Magerlein
  • Matthias Reumann
  • Hui-Fang Wen
  • John Jeremy Rice

Abstract

We have developed the capability to rapidly simulate cardiac electrophysiological phenomena in a human heart discretised at a resolution comparable with the length of a cardiac myocyte. Previous scientific investigation has generally invoked simplified geometries or coarse-resolution hearts, with simulation duration limited to 10s of heartbeats. Using state-of-the-art high-performance computing techniques coupled with one of the most powerful computers available (the 20 PFlop/s IBM BlueGene/Q at Lawrence Livermore National Laboratory), high-resolution simulation of the human heart can now be carried out over 1200 times faster compared with published results in the field. We demonstrate the utility of this capability by simulating, for the first time, the formation of transmural re-entrant waves in a 3D human heart. Such wave patterns are thought to underlie Torsades de Pointes, an arrhythmia that indicates a high risk of sudden cardiac death. Our new simulation capability has the potential to impact a multitude of applications in medicine, pharmaceuticals and implantable devices.

Suggested Citation

  • David F. Richards & James N. Glosli & Erik W. Draeger & Arthur A. Mirin & Bor Chan & Jean-luc Fattebert & William D. Krauss & Tomas Oppelstrup & Chris J. Butler & John A. Gunnels & Viatcheslav Gurev &, 2013. "Towards real-time simulation of cardiac electrophysiology in a human heart at high resolution," Computer Methods in Biomechanics and Biomedical Engineering, Taylor & Francis Journals, vol. 16(7), pages 802-805, July.
    • Handle: RePEc:taf:gcmbxx:v:16:y:2013:i:7:p:802-805
    DOI: 10.1080/10255842.2013.795556
    as

    Download full text from publisher

    File URL: http://hdl.handle.net/10.1080/10255842.2013.795556
    Download Restriction: Access to full text is restricted to subscribers.
    File URL: https://libkey.io/10.1080/10255842.2013.795556?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Enid Van Nieuwenhuyse & Gunnar Seemann & Alexander V Panfilov & Nele Vandersickel, 2017. "Effects of early afterdepolarizations on excitation patterns in an accurate model of the human ventricles," PLOS ONE, Public Library of Science, vol. 12(12), pages 1-19, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:taf:gcmbxx:v:16:y:2013:i:7:p:802-805. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Chris Longhurst (email available below). General contact details of provider: http://www.tandfonline.com/gcmb .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.