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Numerical simulation of microneedles' insertion into skin

Author

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  • X. Kong
  • P. Zhou
  • C. Wu

Abstract

Microneedles have recently received much attention as a novel way for transdermal drug delivery. In this paper, a numerical simulation of the insertion process of the microneedle into human skin is reported using the finite element method. A multilayer skin model consisting of the stratum corneum, dermis and underlying hypodermis has been developed. The effective stress failure criterion has been coupled with the element deletion technique to predict the complete insertion process. The numerical results show a good agreement with the reported experimental data for the deformation and failure of the skin and the insertion force. The influences of the mechanical properties of the skin and the microneedle geometry (e.g. tip area, wall angle and wall thickness) on the insertion force are discussed. The numerical results are helpful for the optimum design of the microneedles for the transdermal drug delivery system.

Suggested Citation

  • X. Kong & P. Zhou & C. Wu, 2011. "Numerical simulation of microneedles' insertion into skin," Computer Methods in Biomechanics and Biomedical Engineering, Taylor & Francis Journals, vol. 14(09), pages 827-835.
    • Handle: RePEc:taf:gcmbxx:v:14:y:2011:i:09:p:827-835
    DOI: 10.1080/10255842.2010.497144
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