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A Cross-Indication Budget Impact Model of Secukinumab for the Treatment of Psoriasis, Psoriatic Arthritis, Ankylosing Spondylitis and Non-radiographic Axial Spondyloarthritis in Italy

Author

Listed:
  • Paolo Angelo Cortesi

    (University of Milan-Bicocca)

  • Carla Fornari

    (University of Milan-Bicocca)

  • Paolo Gisondi

    (University of Verona)

  • Florenzo Iannone

    (University of Bari, Policlinico)

  • Ippazio Cosimo Antonazzo

    (University of Milan-Bicocca)

  • Elisabetta Aloisi

    (Novartis Farma SpA)

  • Martina Fiocchi

    (Novartis Farma SpA)

  • Daniela Ritrovato

    (Novartis Farma SpA)

  • Lorenzo Giovanni Mantovani

    (University of Milan-Bicocca
    IRCCS Multimedica)

Abstract

Background Recent developments improved outcomes in patients with autoimmune diseases. Biologics were approved as first-line treatment in selected naïve patients with plaque psoriasis (PsO), psoriatic arthritis (PsA), ankylosing spondylitis (AS) and non-radiographic axial spondyloarthritis (nr-axSpA). Among them, secukinumab was most recently approved for treatment of active nr-axSpA in adults. In this work, we assessed the budget impact of new secukinumab treatment options in the Italian market. Methods A cross-indication budget impact model was designed to estimate the effects of adding secukinumab in the Italian market from the National Health System perspective over a 3-year period. The model included all adults with PsO, PsA, AS and nr-axSpA, treated with biologics or biosimilars. It compared costs between two scenarios, secukinumab availability or absence, for the four diseases combined and taken individually. A sensitivity analyses was conducted. Results There were 68,121 adult patients treated with biologics in 2021 and 68,341 in 2023. The budget impact analysis (BIA) on all indications showed a cost reduction of €33.7 million (− 1.5%) over 3 years with the introduction of secukinumab. PsA patients had the highest saving (− €34.9 million), followed by PsO patients (− €7.8 million). Cost saving in PsO patients was balanced by increased budget reported in AS patients (+ €8.0 million). In nr-axSpA patients, secukinumab reported no significant budget increase (+ 1.0%). Conclusion This BIA accounted for the new indication of secukinumab in nr-axSpA patients, reporting no significant changes in the required budget and adding an effective treatment option. Considering all indications, secukinumab is a sustainable treatment option.

Suggested Citation

  • Paolo Angelo Cortesi & Carla Fornari & Paolo Gisondi & Florenzo Iannone & Ippazio Cosimo Antonazzo & Elisabetta Aloisi & Martina Fiocchi & Daniela Ritrovato & Lorenzo Giovanni Mantovani, 2023. "A Cross-Indication Budget Impact Model of Secukinumab for the Treatment of Psoriasis, Psoriatic Arthritis, Ankylosing Spondylitis and Non-radiographic Axial Spondyloarthritis in Italy," PharmacoEconomics - Open, Springer, vol. 7(3), pages 405-416, May.
  • Handle: RePEc:spr:pharmo:v:7:y:2023:i:3:d:10.1007_s41669-023-00404-3
    DOI: 10.1007/s41669-023-00404-3
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    References listed on IDEAS

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    1. Roxanne Cooksey & Muhammad J Husain & Sinead Brophy & Helen Davies & Muhammad A Rahman & Mark D Atkinson & Ceri J Phillips & Stefan Siebert, 2015. "The Cost of Ankylosing Spondylitis in the UK Using Linked Routine and Patient-Reported Survey Data," PLOS ONE, Public Library of Science, vol. 10(7), pages 1-17, July.
    2. Lucia Sara D’Angiolella & Paolo Angelo Cortesi & Alessandra Lafranconi & Mariangela Micale & Sveva Mangano & Giancarlo Cesana & Lorenzo Giovanni Mantovani, 2018. "Cost and Cost Effectiveness of Treatments for Psoriatic Arthritis: A Systematic Literature Review," PharmacoEconomics, Springer, vol. 36(5), pages 567-589, May.
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