IDEAS home Printed from https://ideas.repec.org/a/spr/pharmo/v3y2019i1d10.1007_s41669-018-0084-1.html
   My bibliography  Save this article

Conducting a Time Trade-Off Study Alongside a Clinical Trial: A Case Study and Recommendations

Author

Listed:
  • Jing Shen

    (Newcastle University)

  • Sarah Hill

    (Newcastle University)

  • David Mott

    (Newcastle University
    Office of Health Economics)

  • Matthew Breckons

    (Newcastle University)

  • Luke Vale

    (Newcastle University)

  • Rob Pickard

    (Newcastle University)

Abstract

Time trade-off (TTO) is an established method in health economics to elicit and value individuals’ preferences for different health states. These preferences are expressed in the form of health-state utilities that are typically used to measure health-related quality of life and calculate quality-adjusted life-years in an economic evaluation. The TTO approach to directly elicit health-state utilities is particularly valuable when generic instruments (e.g. EQ-5D) may not fully capture changes in utility in a clinical trial. However, there is limited guidance on how a TTO study should be conducted alongside a clinical trial despite it being a valuable tool. We present an account of the design and development of a TTO study within a clinical trial as a case study. We describe the development of materials needed for the TTO interviews, the piloting of the TTO materials and interview process, and recommendations for future TTO studies. This paper provides a practical guide and reference for future applications of the TTO method alongside a clinical trial.

Suggested Citation

  • Jing Shen & Sarah Hill & David Mott & Matthew Breckons & Luke Vale & Rob Pickard, 2019. "Conducting a Time Trade-Off Study Alongside a Clinical Trial: A Case Study and Recommendations," PharmacoEconomics - Open, Springer, vol. 3(1), pages 5-20, March.
    • Handle: RePEc:spr:pharmo:v:3:y:2019:i:1:d:10.1007_s41669-018-0084-1
    DOI: 10.1007/s41669-018-0084-1
    as

    Download full text from publisher

    File URL: http://link.springer.com/10.1007/s41669-018-0084-1
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1007/s41669-018-0084-1?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Claire Gudex, 1994. "Time trade-off user manual: props and self-completion methods," Working Papers 020cheop, Centre for Health Economics, University of York.
    2. Johanna Cook & Jeff Richardson & Andrew Street, 1994. "A cost utility analysis of treatment options for gallstone disease: Methodological issues and results," Health Economics, John Wiley & Sons, Ltd., vol. 3(3), pages 157-168, May.
    3. Nancy J. Devlin & Koonal K. Shah & Yan Feng & Brendan Mulhern & Ben van Hout, 2018. "Valuing health‐related quality of life: An EQ‐5D‐5L value set for England," Health Economics, John Wiley & Sons, Ltd., vol. 27(1), pages 7-22, January.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Spencer, Anne & Rivero-Arias, Oliver & Wong, Ruth & Tsuchiya, Aki & Bleichrodt, Han & Edwards, Rhiannon Tudor & Norman, Richard & Lloyd, Andrew & Clarke, Philip, 2022. "The QALY at 50: One story many voices," Social Science & Medicine, Elsevier, vol. 296(C).
    2. Attema, Arthur E. & Brouwer, Werner B.F., 2012. "A test of independence of discounting from quality of life," Journal of Health Economics, Elsevier, vol. 31(1), pages 22-34.
    3. Chen, Gang & Ratcliffe, Julie & Milte, Rachel & Khadka, Jyoti & Kaambwa, Billingsley, 2021. "Quality of care experience in aged care: An Australia-Wide discrete choice experiment to elicit preference weights," Social Science & Medicine, Elsevier, vol. 289(C).
    4. Rowen, Donna & Mukuria, Clara & Bray, Nathan & Carlton, Jill & Longworth, Louise & Meads, David & O'Neill, Ciaran & Shah, Koonal & Yang, Yaling, 2022. "Assessing the comparative feasibility, acceptability and equivalence of videoconference interviews and face-to-face interviews using the time trade-off technique," Social Science & Medicine, Elsevier, vol. 309(C).
    5. Olsen, Jan Abel & Lindberg, Marie Hella & Lamu, Admassu Nadew, 2020. "Health and wellbeing in Norway: Population norms and the social gradient," Social Science & Medicine, Elsevier, vol. 259(C).
    6. Carl Tilling & Nancy Devlin & Aki Tsuchiya & Ken Buckingham, 2010. "Protocols for Time Tradeoff Valuations of Health States Worse than Dead: A Literature Review," Medical Decision Making, , vol. 30(5), pages 610-619, September.
    7. Brendan Mulhern & Richard Norman & John Brazier, 2021. "Valuing SF-6Dv2 in Australia Using an International Protocol," PharmacoEconomics, Springer, vol. 39(10), pages 1151-1162, October.
    8. Paul Dolan & Claire Gudex & Paul Kind & Alan Williams, 1995. "A social tariff for EuroQol: results from a UK general population survey," Working Papers 138chedp, Centre for Health Economics, University of York.
    9. Victoria Brennan & Simon Dixon, 2013. "Incorporating Process Utility into Quality Adjusted Life Years: A Systematic Review of Empirical Studies," PharmacoEconomics, Springer, vol. 31(8), pages 677-691, August.
    10. Marisa Santos & Monica A. C. T. Cintra & Andrea L. Monteiro & Braulio Santos & Fernando Gusmão-filho & Mônica Viegas Andrade & Kenya Noronha & Luciane N. Cruz & Suzi Camey & Bernardo Tura & Paul Kin, 2016. "Brazilian Valuation of EQ-5D-3L Health States," Medical Decision Making, , vol. 36(2), pages 253-263, February.
    11. McTaggart-Cowan, Helen & Tsuchiya, Aki & O'Cathain, Alicia & Brazier, John, 2011. "Understanding the effect of disease adaptation information on general population values for hypothetical health states," Social Science & Medicine, Elsevier, vol. 72(11), pages 1904-1912, June.
    12. Guillem López-Casasnovas & José Luis Pinto Prades, 2022. "QALY Maximization and the Social Optimum," Hacienda Pública Española / Review of Public Economics, IEF, vol. 242(3), pages 111-127, September.
    13. Asrul Akmal Shafie & Annushiah Vasan Thakumar, 2020. "Multiplicative modelling of EQ-5D-3L TTO and VAS values," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 21(9), pages 1411-1420, December.
    14. Paul McNamee & Sharon Glendinning & Jonathan Shenfine & Nick Steen & S. Griffin & John Bond, 2004. "Chained time trade-off and standard gamble methods," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 5(1), pages 81-86, February.
    15. Ramesh Lamsal & Jennifer D. Zwicker, 2017. "Economic Evaluation of Interventions for Children with Neurodevelopmental Disorders: Opportunities and Challenges," Applied Health Economics and Health Policy, Springer, vol. 15(6), pages 763-772, December.
    16. Karen Gerard & Katharine Johnston & Jackie Brown, 1999. "The role of a pre‐scored multi‐attribute health classification measure in validating condition‐specific health state descriptions," Health Economics, John Wiley & Sons, Ltd., vol. 8(8), pages 685-699, December.
    17. Brazier, John & Rowen, Donna & Tsuchiya, Aki & Yang, Yaling & Young, Tracy A., 2011. "The impact of adding an extra dimension to a preference-based measure," Social Science & Medicine, Elsevier, vol. 73(2), pages 245-253, July.
    18. Tianxin Pan & Brendan Mulhern & Rosalie Viney & Richard Norman & Janel Hanmer & Nancy Devlin, 2022. "A Comparison of PROPr and EQ-5D-5L Value Sets," PharmacoEconomics, Springer, vol. 40(3), pages 297-307, March.
    19. Diego Ossa & Andrew Briggs & Emma McIntosh & Warren Cowell & Tim Littlewood & Mark Sculpher, 2007. "Recombinant Erythropoietin for Chemotherapy-Related Anaemia," PharmacoEconomics, Springer, vol. 25(3), pages 223-237, March.
    20. Sanjeewa Kularatna & Jennifer A Whitty & Newell W Johnson & Ruwan Jayasinghe & Paul A Scuffham, 2014. "EQ-5D-3L Derived Population Norms for Health Related Quality of Life in Sri Lanka," PLOS ONE, Public Library of Science, vol. 9(11), pages 1-12, November.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:spr:pharmo:v:3:y:2019:i:1:d:10.1007_s41669-018-0084-1. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.springer.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.