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Conducting a Time Trade-Off Study Alongside a Clinical Trial: A Case Study and Recommendations

Author

Listed:
  • Jing Shen

    (Newcastle University)

  • Sarah Hill

    (Newcastle University)

  • David Mott

    (Newcastle University
    Office of Health Economics)

  • Matthew Breckons

    (Newcastle University)

  • Luke Vale

    (Newcastle University)

  • Rob Pickard

    (Newcastle University)

Abstract

Time trade-off (TTO) is an established method in health economics to elicit and value individuals’ preferences for different health states. These preferences are expressed in the form of health-state utilities that are typically used to measure health-related quality of life and calculate quality-adjusted life-years in an economic evaluation. The TTO approach to directly elicit health-state utilities is particularly valuable when generic instruments (e.g. EQ-5D) may not fully capture changes in utility in a clinical trial. However, there is limited guidance on how a TTO study should be conducted alongside a clinical trial despite it being a valuable tool. We present an account of the design and development of a TTO study within a clinical trial as a case study. We describe the development of materials needed for the TTO interviews, the piloting of the TTO materials and interview process, and recommendations for future TTO studies. This paper provides a practical guide and reference for future applications of the TTO method alongside a clinical trial.

Suggested Citation

  • Jing Shen & Sarah Hill & David Mott & Matthew Breckons & Luke Vale & Rob Pickard, 2019. "Conducting a Time Trade-Off Study Alongside a Clinical Trial: A Case Study and Recommendations," PharmacoEconomics - Open, Springer, vol. 3(1), pages 5-20, March.
    • Handle: RePEc:spr:pharmo:v:3:y:2019:i:1:d:10.1007_s41669-018-0084-1
    DOI: 10.1007/s41669-018-0084-1
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    References listed on IDEAS

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    1. Johanna Cook & Jeff Richardson & Andrew Street, 1994. "A cost utility analysis of treatment options for gallstone disease: Methodological issues and results," Health Economics, John Wiley & Sons, Ltd., vol. 3(3), pages 157-168, May.
    2. Claire Gudex, 1994. "Time trade-off user manual: props and self-completion methods," Working Papers 020cheop, Centre for Health Economics, University of York.
    3. Nancy J. Devlin & Koonal K. Shah & Yan Feng & Brendan Mulhern & Ben van Hout, 2018. "Valuing health‐related quality of life: An EQ‐5D‐5L value set for England," Health Economics, John Wiley & Sons, Ltd., vol. 27(1), pages 7-22, January.
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