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Cost-Effectiveness Analysis of Prostate Cancer Screening in the UK: A Decision Model Analysis Based on the CAP Trial

Author

Listed:
  • Edna Keeney

    (University of Bristol)

  • Sabina Sanghera

    (University of Bristol)

  • Richard M. Martin

    (University of Bristol
    NIHR Bristol Biomedical Research Centre at University Hospitals Bristol and Weston NHS Foundation Trust and the University of Bristol)

  • Roman Gulati

    (Fred Hutchinson Cancer Research Center)

  • Fredrik Wiklund

    (Karolinska Institute)

  • Eleanor I. Walsh

    (University of Bristol)

  • Jenny L. Donovan

    (University of Bristol)

  • Freddie Hamdy

    (University of Oxford)

  • David E. Neal

    (University of Oxford)

  • J. Athene Lane

    (University of Bristol)

  • Emma L. Turner

    (University of Bristol)

  • Howard Thom

    (University of Bristol)

  • Mark S. Clements

    (Karolinska Institute)

Abstract

Background and Objective Most guidelines in the UK, Europe and North America do not recommend organised population-wide screening for prostate cancer. Prostate-specific antigen-based screening can reduce prostate cancer-specific mortality, but there are concerns about overdiagnosis, overtreatment and economic value. The aim was therefore to assess the cost effectiveness of eight potential screening strategies in the UK. Methods We used a cost-utility analysis with an individual-based simulation model. The model was calibrated to data from the 10-year follow-up of the Cluster Randomised Trial of PSA Testing for Prostate Cancer (CAP). Treatment effects were modelled using data from the Prostate Testing for Cancer and Treatment (ProtecT) trial. The participants were a hypothetical population of 10 million men in the UK followed from age 30 years to death. The strategies were: no screening; five age-based screening strategies; adaptive screening, where men with an initial prostate-specific antigen level of

Suggested Citation

  • Edna Keeney & Sabina Sanghera & Richard M. Martin & Roman Gulati & Fredrik Wiklund & Eleanor I. Walsh & Jenny L. Donovan & Freddie Hamdy & David E. Neal & J. Athene Lane & Emma L. Turner & Howard Thom, 2022. "Cost-Effectiveness Analysis of Prostate Cancer Screening in the UK: A Decision Model Analysis Based on the CAP Trial," PharmacoEconomics, Springer, vol. 40(12), pages 1207-1220, December.
    • Handle: RePEc:spr:pharme:v:40:y:2022:i:12:d:10.1007_s40273-022-01191-1
    DOI: 10.1007/s40273-022-01191-1
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