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The Potential Cost Effectiveness of Different Dengue Vaccination Programmes in Malaysia: A Value-Based Pricing Assessment Using Dynamic Transmission Mathematical Modelling

Author

Listed:
  • Asrul Akmal Shafie

    (Universiti Sains Malaysia (USM))

  • Hui Yee Yeo

    (Universiti Sains Malaysia (USM))

  • Laurent Coudeville

    (Sanofi Pasteur SA)

  • Lucas Steinberg

    (Sanofi Pasteur Malaysia)

  • Balvinder Singh Gill

    (Ministry of Health Malaysia)

  • Rohani Jahis

    (Ministry of Health Malaysia)

  • Amar-Singh HSS

    (Hospital Raja Permaisuri Bainun Ipoh, Jalan Hospital)

Abstract

Background Dengue disease poses a great economic burden in Malaysia. Methods This study evaluated the cost effectiveness and impact of dengue vaccination in Malaysia from both provider and societal perspectives using a dynamic transmission mathematical model. The model incorporated sensitivity analyses, Malaysia-specific data, evidence from recent phase III studies and pooled efficacy and long-term safety data to refine the estimates from previous published studies. Unit costs were valued in $US, year 2013 values. Results Six vaccination programmes employing a three-dose schedule were identified as the most likely programmes to be implemented. In all programmes, vaccination produced positive benefits expressed as reductions in dengue cases, dengue-related deaths, life-years lost, disability-adjusted life-years and dengue treatment costs. Instead of incremental cost-effectiveness ratios (ICERs), we evaluated the cost effectiveness of the programmes by calculating the threshold prices for a highly cost-effective strategy [ICER

Suggested Citation

  • Asrul Akmal Shafie & Hui Yee Yeo & Laurent Coudeville & Lucas Steinberg & Balvinder Singh Gill & Rohani Jahis & Amar-Singh HSS, 2017. "The Potential Cost Effectiveness of Different Dengue Vaccination Programmes in Malaysia: A Value-Based Pricing Assessment Using Dynamic Transmission Mathematical Modelling," PharmacoEconomics, Springer, vol. 35(5), pages 575-589, May.
    • Handle: RePEc:spr:pharme:v:35:y:2017:i:5:d:10.1007_s40273-017-0487-3
    DOI: 10.1007/s40273-017-0487-3
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    Cited by:

    1. Liv Solvår Nymark & Alex Miller & Anna Vassall, 2021. "Inclusion of Additional Unintended Consequences in Economic Evaluation: A Systematic Review of Immunization and Tuberculosis Cost-Effectiveness Analyses," PharmacoEconomics - Open, Springer, vol. 5(4), pages 587-603, December.
    2. Auliya A. Suwantika & Angga P. Kautsar & Woro Supadmi & Neily Zakiyah & Rizky Abdulah & Mohammad Ali & Maarten J. Postma, 2020. "Cost-Effectiveness of Dengue Vaccination in Indonesia: Considering Integrated Programs with Wolbachia -Infected Mosquitos and Health Education," IJERPH, MDPI, vol. 17(12), pages 1-15, June.

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