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Systematic Literature Review of the Methods Used to Compare Newer Second-Generation Agents for the Management of Schizophrenia: A focus on Health Technology Assessment

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  • Gregory Kruse
  • Bruce Wong
  • Mei Duh
  • Patrick Lefebvre
  • Marie-Hélène Lafeuille
  • John Fastenau

Abstract

This review of comparative effectiveness studies of second-generation antipsychotic agents for schizophrenic patients revealed a wide range of study types, study methodologies, and outcomes. For traditional efficacy outcomes and select safety outcomes, there is strong evidence from many well-conducted studies; however, there are fewer studies of types preferred by HTA with limited head-to-head comparisons and a higher risk of bias in the execution of these studies. Copyright Springer International Publishing Switzerland 2015

Suggested Citation

  • Gregory Kruse & Bruce Wong & Mei Duh & Patrick Lefebvre & Marie-Hélène Lafeuille & John Fastenau, 2015. "Systematic Literature Review of the Methods Used to Compare Newer Second-Generation Agents for the Management of Schizophrenia: A focus on Health Technology Assessment," PharmacoEconomics, Springer, vol. 33(10), pages 1049-1067, October.
    • Handle: RePEc:spr:pharme:v:33:y:2015:i:10:p:1049-1067
    DOI: 10.1007/s40273-015-0285-8
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    References listed on IDEAS

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    1. DE RIDDER, Annemieke & DE GRAEVE, Diana, 2007. "Comparing the cost-effectiveness of Haloperidol, Risperidone and Olanzapine in the treatment of schizophrenia using the net-benefit regression approach," Working Papers 2007012, University of Antwerp, Faculty of Business and Economics.
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    1. Ifigeneia Mavranezouli, 2010. "A Review and Critique of Studies Reporting Utility Values for Schizophrenia-Related Health States," PharmacoEconomics, Springer, vol. 28(12), pages 1109-1121, December.

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