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Influence of Pharmacogenomic Profiling Prior to Pharmaceutical Treatment in Metastatic Colorectal Cancer on Cost Effectiveness

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  • Martin Frank
  • Thomas Mittendorf

Abstract

Pharmacogenomic profiling has the potential to improve the cost effectiveness of pharmaceutical treatment in mCRC. Hence, quantification of the economic impact of stratified medicine as well as cost-effectiveness analyses of pharmacogenomic profiling are becoming more important. Nevertheless, the methods applied in cost-effectiveness evaluations for the usage of predictive biomarkers for patient selection as well as the level of evidence required to determine clinical effectiveness are areas for further research. However, mCRC is one of the first indications in which stratified therapies are used in clinical practice. Thus, clinical and economic experiences could be helpful when adopting pharmacogenomic profiling into clinical practice for other indications. Copyright Springer International Publishing Switzerland 2013

Suggested Citation

  • Martin Frank & Thomas Mittendorf, 2013. "Influence of Pharmacogenomic Profiling Prior to Pharmaceutical Treatment in Metastatic Colorectal Cancer on Cost Effectiveness," PharmacoEconomics, Springer, vol. 31(3), pages 215-228, March.
    • Handle: RePEc:spr:pharme:v:31:y:2013:i:3:p:215-228
    DOI: 10.1007/s40273-012-0017-2
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    Cited by:

    1. Peter Hall & Christopher McCabe, 2013. "What Evidence Is There for the Reimbursement of Personalised Medicine?," PharmacoEconomics, Springer, vol. 31(3), pages 181-183, March.
    2. Gregory S. Zaric, 2016. "Cost Implications of Value-Based Pricing for Companion Diagnostic Tests in Precision Medicine," PharmacoEconomics, Springer, vol. 34(7), pages 635-644, July.
    3. Mikyung Kelly Seo & John Cairns, 2018. "Do cancer biomarkers make targeted therapies cost-effective? A systematic review in metastatic colorectal cancer," PLOS ONE, Public Library of Science, vol. 13(9), pages 1-23, September.

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