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Impact of Transdermal Oxybutynin on Work Productivity in Patients with Overactive Bladder

Author

Listed:
  • Laura Pizzi
  • Amy Talati
  • Eric Gemmen
  • Naomi Dahl
  • Thomas Bunz
  • Peter Sand

Abstract

Background: Overactive bladder syndrome (OAB) is a common condition affecting a significant number of working adults, resulting in increased healthcare utilization, reduced quality of life and decreased work productivity. The MATRIX study was a large, prospective, community-based, observational US study aimed at evaluating the impact of oxybutynin transdermal system (OXY-TDS). In this paper, we report on productivity findings among working adults in MATRIX. Methods: This study enrolled 2878 adults (aged ≥18 years) with symptoms of OAB from 327 practice sites throughout the US. All subjects received OXY-TDS (3.9 mg/day up to 6 months). Baseline versus end-of-study productivity was measured using the Work Productivity Questionnaire (WPQ). The WPQ includes a subset of questions from the Work Limitations Questionnaire (WLQ) and consists of four scales: (i) physical; (ii) time management; (iii) mental; and (iv) output demands. Overall productivity was measured by the work productivity index score (WPQ Index; a summary score based on scales) and work productivity loss score (WPLS; a measure of reduced output compared with healthy workers). Psychometric performance of the WPQ instrument is also reported, since this study represents the first use of the tool. Results: Of the participants, 52% were of working age (18–65 years) and 38.6% were employed. A total of 1112 working adults participated in MATRIX and were included in this analysis. They had a mean age of 52.4 years; 92.2% were female and 80.9% were Caucasian. Subjects who reported that they were most affected by OAB were also most impaired at work. After OXY-TDS treatment, participants experienced significant improvements in mean scores for all four WPQ scales (p ≤0.0002) and the mean WPQ Index decreased from 8.2 to 5.5 (p > 0.0001). In addition, the WPLS decreased from 7.7% to 5.2% (p > 0.0001), indicating improvement in work function with OXY-TDS treatment. Conclusion: OAB contributes to decreased work productivity due to job interruptions as well as fatigue. OXY-TDS may result in productivity improvement when patients receive 3.9 mg/day via twice weekly patch application for up to 6 months. Copyright Adis Data Information BV 2009

Suggested Citation

  • Laura Pizzi & Amy Talati & Eric Gemmen & Naomi Dahl & Thomas Bunz & Peter Sand, 2009. "Impact of Transdermal Oxybutynin on Work Productivity in Patients with Overactive Bladder," PharmacoEconomics, Springer, vol. 27(4), pages 329-339, April.
    • Handle: RePEc:spr:pharme:v:27:y:2009:i:4:p:329-339
    DOI: 10.2165/00019053-200927040-00005
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