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The Importance of Achieving Additional Drug Benefits at a Reasonable Cost

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  • Nick Freemantle
  • James Mason

Abstract

Fluoxetine continues to be remarkably successful; greater volumes of this drug are sold than for any other antidepressant in the world. Prozac® has also become a household name. In this article we examine the circumstances that surround this success, and the evidence base that supports it. Rather than being a major step forward in the treatment for depression, the evidence for fluoxetine and for the selective serotonin reuptake inhibitors in general suggest at best a modest improvement in tolerability, with no evidence of improved efficacy. We note that the road to successwas not problem free for fluoxetine, and highlight the response of the sponsor in the development of subsequent drugs for CNS disorders. Copyright Adis International Limited 2000

Suggested Citation

  • Nick Freemantle & James Mason, 2000. "The Importance of Achieving Additional Drug Benefits at a Reasonable Cost," PharmacoEconomics, Springer, vol. 17(4), pages 319-324, April.
    • Handle: RePEc:spr:pharme:v:17:y:2000:i:4:p:319-324
    DOI: 10.2165/00019053-200017040-00001
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    References listed on IDEAS

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    1. Freemantle, Nick, 1996. "Are decisions taken by health care professionals rational? A non systematic review of experimental and quasi experimental literature," Health Policy, Elsevier, vol. 38(2), pages 71-81, November.
    2. Freemantle, Nick, 1999. "Does the UK National Health Service need a fourth hurdle for pharmaceutical reimbursement to encourage the more efficient prescribing of pharmaceuticals?," Health Policy, Elsevier, vol. 46(3), pages 255-265, March.
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