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Modeling the mechanism pathways of first line drug in Tuberculosis using Petri nets

Author

Listed:
  • Gajendra Pratap Singh

    (Jawaharlal Nehru University)

  • Madhuri Jha

    (Jawaharlal Nehru University)

  • Mamtesh Singh

    (Gargi College (University of Delhi))

  • Naina

    (Jawaharlal Nehru University)

Abstract

Multi-Drug Resistant (MDR) and Extensively Drug-Resistant (XDR) in Tuberculosis (TB) is still a big threat worldwide, as it remains one of the leading causes of death. The main reason behind this is the Mycobacterium tuberculosis bacteria (Mtb) is being resistant towards first line drug (FLD). This is because of the mutation in certain genes like katG, pncA, rpoB, embABC. To have a better understanding of the mechanism behind the susceptibility and resistivity of drugs involved in FLD, we propose a graphical approach of modeling the whole process by using Petri net. The analysis of the model helps in improving the new drug techniques on the way to decrease the rate of MDR-TB and XDR-TB.

Suggested Citation

  • Gajendra Pratap Singh & Madhuri Jha & Mamtesh Singh & Naina, 2020. "Modeling the mechanism pathways of first line drug in Tuberculosis using Petri nets," International Journal of System Assurance Engineering and Management, Springer;The Society for Reliability, Engineering Quality and Operations Management (SREQOM),India, and Division of Operation and Maintenance, Lulea University of Technology, Sweden, vol. 11(2), pages 313-324, July.
  • Handle: RePEc:spr:ijsaem:v:11:y:2020:i:2:d:10.1007_s13198-019-00940-4
    DOI: 10.1007/s13198-019-00940-4
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    References listed on IDEAS

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    1. Sakshi Gupta & Gajendra Pratap Singh & Sunita Kumawat, 2019. "Petri Net Recommender System to Model Metabolic Pathway of Polyhydroxyalkanoates," International Journal of Knowledge and Systems Science (IJKSS), IGI Global, vol. 10(2), pages 42-59, April.
    2. Gajendra Pratap Singh & Sujit Kumar Singh, 2019. "Petri Net Recommender System for Generating of Perfect Binary Tree," International Journal of Knowledge and Systems Science (IJKSS), IGI Global, vol. 10(2), pages 1-12, April.
    3. Sangita Kansal & Mukti Acharya & Gajendra Pratap Singh, 2012. "Boolean Petri Nets," Chapters, in: Pawel Pawlewski (ed.), Petri Nets - Manufacturing and Computer Science, IntechOpen.
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    Cited by:

    1. Madhuri Jha & Mamtesh Singh & Gajendra Pratap Singh, 2022. "Modeling of second-line drug behavior in the treatment of tuberculosis using Petri net," International Journal of System Assurance Engineering and Management, Springer;The Society for Reliability, Engineering Quality and Operations Management (SREQOM),India, and Division of Operation and Maintenance, Lulea University of Technology, Sweden, vol. 13(2), pages 810-819, June.

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