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Cost of hemophilia A in Brazil: a microcosting study

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  • Ana Paula Beck Silva Etges

    (National Institute of Science and Technology for Health Technology Assessment (IATS) - CNPq/Brazil (project: 465518/2014-1)
    Universidade Federal do Rio Grande do Sul School of Medicine)

  • Nayê Balzan Schneider

    (National Institute of Science and Technology for Health Technology Assessment (IATS) - CNPq/Brazil (project: 465518/2014-1)
    Universidade Federal do Rio Grande do Sul School of Medicine)

  • Erica Caetano Roos

    (National Institute of Science and Technology for Health Technology Assessment (IATS) - CNPq/Brazil (project: 465518/2014-1)
    Universidade Federal do Rio Grande do Sul)

  • Miriam Allein Zago Marcolino

    (National Institute of Science and Technology for Health Technology Assessment (IATS) - CNPq/Brazil (project: 465518/2014-1)
    Universidade Federal do Rio Grande do Sul School of Medicine)

  • Margareth Castro Ozelo

    (University of Campinas)

  • Mariana Midori Takahashi Hosokawa Nikkuni

    (University of Campinas)

  • Luany Elvira Mesquita Carvalho

    (Ceará Hematology and Hemotherapy Center-HEMOCE)

  • Tatyane Oliveira Rebouças

    (Ceará Hematology and Hemotherapy Center-HEMOCE)

  • Monica Hermida Cerqueira

    (Instituto Estadual de Hematologia Arthur de Siqueira Cavalcanti-HEMORIO)

  • Veronica Mata

    (Roche Produtos Farmacêuticos)

  • Carisi Anne Polanczyk

    (National Institute of Science and Technology for Health Technology Assessment (IATS) - CNPq/Brazil (project: 465518/2014-1)
    Universidade Federal do Rio Grande do Sul School of Medicine)

Abstract

Background Patients with Hemophilia are continually monitored at treatment centers to avoid and control bleeding episodes. This study estimated the direct and indirect costs per patient with hemophilia A in Brazil and evaluated the cost variability across different age groups. Methods A prospective observational research was conducted with retrospective data collection of patients assisted at three referral blood centers in Brazil. Time-driven Activity-based Costing method was used to analyze direct costs, while indirect costs were estimated based on interviews with family and caregivers. Cost per patient was analyzed according to age categories, stratified into 3 groups (0–11;12–18 or older than 19 years old). The non-parametric Mann-Whitney test was used to confirm the differences in costs across groups. Results Data from 140 hemophilia A patients were analyzed; 53 were 0–11 years, 29 were 12–18 years, and the remaining were older than 19 years. The median cost per patient per year was R$450,831 (IQR R$219,842; R$785,149; $174,566), being possible to confirm age as a cost driver: older patients had higher costs than younger’s (p = 0.001; median cost: 0–11 yrs R$299,320; 12–18 yrs R$521,936; ≥19 yrs R$718,969). Conclusion This study is innovative in providing cost information for hemophilia A using a microcosting technique. The variation in costs across patient age groups can sustain more accurate health policies driven to increase access to cutting-edge technologies and reduce the burden of the disease.

Suggested Citation

  • Ana Paula Beck Silva Etges & Nayê Balzan Schneider & Erica Caetano Roos & Miriam Allein Zago Marcolino & Margareth Castro Ozelo & Mariana Midori Takahashi Hosokawa Nikkuni & Luany Elvira Mesquita Carv, 2024. "Cost of hemophilia A in Brazil: a microcosting study," Health Economics Review, Springer, vol. 14(1), pages 1-8, December.
  • Handle: RePEc:spr:hecrev:v:14:y:2024:i:1:d:10.1186_s13561-024-00539-x
    DOI: 10.1186/s13561-024-00539-x
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    References listed on IDEAS

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    1. Drummond, Michael F. & Sculpher, Mark J. & Torrance, George W. & O'Brien, Bernie J. & Stoddart, Greg L., 2005. "Methods for the Economic Evaluation of Health Care Programmes," OUP Catalogue, Oxford University Press, edition 3, number 9780198529453.
    2. Keel, George & Savage, Carl & Rafiq, Muhammad & Mazzocato, Pamela, 2017. "Time-driven activity-based costing in health care: A systematic review of the literature," Health Policy, Elsevier, vol. 121(7), pages 755-763.
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