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Studying the emergence of invasiveness in tumours using game theory

Author

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  • D. Basanta
  • H. Hatzikirou
  • A. Deutsch

Abstract

Tumour cells have to acquire a number of capabilities if a neoplasm is to become a cancer. One of these key capabilities is increased motility which is needed for invasion of other tissues and metastasis. This paper presents a qualitative mathematical model based on game theory and computer simulations using cellular automata. With this model we study the circumstances under which mutations that confer increased motility to cells can spread through a tumour made of rapidly proliferating cells. The analysis suggests therapies that could help prevent the progression towards malignancy and invasiveness of benign tumours. Copyright EDP Sciences/Società Italiana di Fisica/Springer-Verlag 2008

Suggested Citation

  • D. Basanta & H. Hatzikirou & A. Deutsch, 2008. "Studying the emergence of invasiveness in tumours using game theory," The European Physical Journal B: Condensed Matter and Complex Systems, Springer;EDP Sciences, vol. 63(3), pages 393-397, June.
    • Handle: RePEc:spr:eurphb:v:63:y:2008:i:3:p:393-397
    DOI: 10.1140/epjb/e2008-00249-y
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    Citations

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    Cited by:

    1. Li You & Maximilian von Knobloch & Teresa Lopez & Vanessa Peschen & Sidney Radcliffe & Praveen Koshy Sam & Frank Thuijsman & Kateřina Staňková & Joel S. Brown, 2019. "Including Blood Vasculature into a Game-Theoretic Model of Cancer Dynamics," Games, MDPI, vol. 10(1), pages 1-22, March.
    2. Javad Salimi Sartakhti & Mohammad Hossein Manshaei & Marco Archetti, 2018. "Game Theory of Tumor–Stroma Interactions in Multiple Myeloma: Effect of Nonlinear Benefits," Games, MDPI, vol. 9(2), pages 1-11, May.
    3. Marco Archetti, 2018. "How to Analyze Models of Nonlinear Public Goods," Games, MDPI, vol. 9(2), pages 1-15, April.
    4. Elena Hurlbut & Ethan Ortega & Igor V. Erovenko & Jonathan T. Rowell, 2018. "Game Theoretical Model of Cancer Dynamics with Four Cell Phenotypes," Games, MDPI, vol. 9(3), pages 1-16, September.
    5. Pranav I. Warman & Artem Kaznatcheev & Arturo Araujo & Conor C. Lynch & David Basanta, 2018. "Fractionated Follow-Up Chemotherapy Delays the Onset of Resistance in Bone Metastatic Prostate Cancer," Games, MDPI, vol. 9(2), pages 1-10, April.

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