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Psychometric performance of EQ-5D-5L and SF-6Dv2 in patients with lymphoma in China

Author

Listed:
  • Aixue Zhang

    (Fudan University
    National Health Commission of the People’s Republic of China (Fudan University))

  • Jing Li

    (Fudan University)

  • Zhuxin Mao

    (University of Antwerp)

  • Zitong Wang

    (Fudan University)

  • Jing Wu

    (Tianjin University)

  • Nan Luo

    (National University of Singapore)

  • Peng Liu

    (Fudan University)

  • Pei Wang

    (Fudan University
    National Health Commission of the People’s Republic of China (Fudan University))

Abstract

Aim To assess and compare the measurement properties of EQ-5D-5L and SF-6Dv2 among lymphoma patients in China. Methods A face-to-face survey of Chinese lymphoma patients was conducted at baseline (all types) and follow-up (diffuse large B-cell). EQ-5D-5L and SF-6Dv2 health utility scores (HUSs) were calculated using the respective Chinese value sets. Ceiling effect was assessed by calculating the percentage of respondents reporting the optimal health state. Convergent validity of EQ-5D-5L and SF-6Dv2 was assessed using the Spearman rank correlation coefficient (r) with QLQ-C30 as a calibration standard. Known-groups validity of the two HUSs was evaluated by comparing their scores of patients with different conditions; and their sensitivity was further assessed in the known-groups using relative efficiency (RE). Test–retest reliability and responsiveness was tested using ICC and standardized response mean (SRM), respectively. Results Altogether 200 patients were enrolled at baseline and 78 were followed up. No ceiling effect was found for SF-6Dv2 compared to 24.5% for EQ-5D-5L. Correlation between the two HUSs and with QLQ-C30 score was strong (r > 0.5). Each dimension of EQ-5D-5L and SF-6Dv2 had moderate or greater correlations with similar dimensions of QLQ-C30 (r > 0.35). Both EQ-5D-5L and SF-6Dv2 could only a minority known-groups, and the latter may have better sensitivity. EQ-5D-5L had better test–retest reliability (ICC = 0.939); while both of them were responsive to patients with worsened and improved clinical status. Conclusions EQ-5D-5L and SF-6Dv2 were found to have good convergent validity and responsiveness, while EQ-5D-5L had better test–retest reliability and higher ceiling effect. Not enough evidence indicates which of the two measures has better known-group validity and sensitivity.

Suggested Citation

  • Aixue Zhang & Jing Li & Zhuxin Mao & Zitong Wang & Jing Wu & Nan Luo & Peng Liu & Pei Wang, 2024. "Psychometric performance of EQ-5D-5L and SF-6Dv2 in patients with lymphoma in China," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 25(9), pages 1471-1484, December.
    • Handle: RePEc:spr:eujhec:v:25:y:2024:i:9:d:10.1007_s10198-024-01672-4
    DOI: 10.1007/s10198-024-01672-4
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    References listed on IDEAS

    as
    1. Emily McDool & Clara Mukuria & John Brazier, 2021. "A Comparison of the SF-6Dv2 and SF-6D UK Utility Values in a Mixed Patient and Healthy Population," PharmacoEconomics, Springer, vol. 39(8), pages 929-940, August.
    2. Jing Wu & Shitong Xie & Xiaoning He & Gang Chen & Gengliang Bai & Da Feng & Ming Hu & Jie Jiang & Xiaohui Wang & Hongyan Wu & Qunhong Wu & John E. Brazier, 2021. "Valuation of SF-6Dv2 Health States in China Using Time Trade-off and Discrete-Choice Experiment with a Duration Dimension," PharmacoEconomics, Springer, vol. 39(5), pages 521-535, May.
    3. Richard Huan Xu & Dong Dong & Nan Luo & Eliza Lai-Yi Wong & Yushan Wu & Siyue Yu & Renchi Yang & Junshuai Liu & Huiqin Yuan & Shuyang Zhang, 2021. "Evaluating the psychometric properties of the EQ-5D-5L and SF-6D among patients with haemophilia," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 22(4), pages 547-557, June.
    4. Fan Yang & Titus Lau & Evan Lee & A. Vathsala & Kee Chia & Nan Luo, 2015. "Comparison of the preference-based EQ-5D-5L and SF-6D in patients with end-stage renal disease (ESRD)," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 16(9), pages 1019-1026, December.
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    More about this item

    Keywords

    Lymphoma; EQ-5D-5L; SF-6Dv2; Measurement properties; Health-related quality of life;
    All these keywords.

    JEL classification:

    • I1 - Health, Education, and Welfare - - Health

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