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Disutility of injectable therapies in obesity and type 2 diabetes mellitus: general population preferences in the UK, Canada, and China

Author

Listed:
  • Phil McEwan

    (Health Economics and Outcomes Research Ltd)

  • James Baker-Knight

    (Novo Nordisk A/S)

  • Björg Ásbjörnsdóttir

    (Novo Nordisk A/S)

  • Yunni Yi

    (Adelphi Values PROVE)

  • Aimee Fox

    (Adelphi Values PROVE)

  • Robin Wyn

    (Adelphi Values PROVE)

Abstract

Introduction Once-daily and once-weekly injectable glucagon-like peptide-1 receptor agonist therapies (GLP-1 RAs) are established in obesity and type 2 diabetes mellitus (T2DM). In T2DM, both once-daily and once-weekly insulin are expected to be available. This study elicited utilities associated with these treatment regimens from members of the general public in the UK, Canada, and China, to quantify administration-related disutility of more-frequent injectable treatment, and allow economic modelling. Methods Two anchor states (no pharmacological treatment), and seven treatment states (daily oral tablet and generic injectable regimens of variable frequency), with identical outcomes were tested A broadly representative sample of the general public in each country participated (excluding individuals with diabetes or pharmacologically treated obesity). An adapted Measurement and Valuation of Health protocol was administered 1:1 in web-enabled interviews by trained moderators: visual analogue scale (VAS) as a “warm-up”, and time trade-off (TTO) using a 20-year time horizon for utility elicitation. Results A total of 310 individuals participated. The average disutility of once-daily versus once-weekly GLP-1 RA was − 0.048 in obesity and − 0.033 in T2DM; the corresponding average disutility for insulin was − 0.064. Disutilities were substantially greater in China, relative to UK and Canada. Discussion Within obesity and T2DM, more-frequent treatment health states had lower utility. Scores by VAS also followed a logical order. The generated utility values are suitable for use in modelling injectable therapy regimens in obesity and T2DM, due to the use of generic descriptions and assumption of equal efficacy. Future research could examine the reasons for greater administration-related disutility in China.

Suggested Citation

  • Phil McEwan & James Baker-Knight & Björg Ásbjörnsdóttir & Yunni Yi & Aimee Fox & Robin Wyn, 2023. "Disutility of injectable therapies in obesity and type 2 diabetes mellitus: general population preferences in the UK, Canada, and China," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 24(2), pages 187-196, March.
    • Handle: RePEc:spr:eujhec:v:24:y:2023:i:2:d:10.1007_s10198-022-01470-w
    DOI: 10.1007/s10198-022-01470-w
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    References listed on IDEAS

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    1. Kristina Boye & Louis Matza & Kimberly Walter & Kate Brunt & Andrew Palsgrove & Aodan Tynan, 2011. "Utilities and disutilities for attributes of injectable treatments for type 2 diabetes," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 12(3), pages 219-230, June.
    2. Hsiang-Wen Lin & Chia-Ing Li & Fang- Ju Lin & Jen-Yu Chang & Churn-Shiouh Gau & Nan Luo & A Simon Pickard & Juan M Ramos Goñi & Chao-Hsiun Tang & Chien-Ning Hsu, 2018. "Valuation of the EQ-5D-5L in Taiwan," PLOS ONE, Public Library of Science, vol. 13(12), pages 1-16, December.
    3. P. Wang & M. Li & G. Liu & J. Thumboo & N. Luo, 2015. "Do Chinese have similar health-state preferences? A comparison of mainland Chinese and Singaporean Chinese," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 16(8), pages 857-863, November.
    4. Mark Oppe & Kim Rand-Hendriksen & Koonal Shah & Juan M. Ramos‐Goñi & Nan Luo, 2016. "EuroQol Protocols for Time Trade-Off Valuation of Health Outcomes," PharmacoEconomics, Springer, vol. 34(10), pages 993-1004, October.
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    More about this item

    Keywords

    Time trade-off (TTO); Type 2 diabetes mellitus (T2DM); Obesity; Insulin; GLP-1 receptor agonist (GLP-1 RA);
    All these keywords.

    JEL classification:

    • I10 - Health, Education, and Welfare - - Health - - - General

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