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Healthcare resource utilization and associated cost of patients with bone metastases from solid tumors who are naïve to bone-targeting agents: a comparative analysis of patients with and without skeletal-related events

Author

Listed:
  • Fränce Hardtstock

    (Ingress-Health HWM GmbH)

  • Zeki Kocaata

    (Ingress-Health HWM GmbH)

  • Thomas Wilke

    (IPAM e.V., University of Wismar)

  • Axel Dittmar

    (IPAM e.V., University of Wismar)

  • Marco Ghiani

    (IPAM e.V., University of Wismar)

  • Vasily Belozeroff

    (Amgen Inc.)

  • David J. Harrison

    (Amgen Inc.)

  • Ulf Maywald

    (AOK PLUS)

  • Hans Tesch

    (Centrum for Hematology and Oncology)

Abstract

Background This study analyzes the impact of skeletal-related events (SRE) on healthcare resource utilization (HCRU) and costs incurred by patients with bone metastases (BM) from solid tumors (ST), who are therapy-naïve to bone targeting agents (BTAs). Methods German claims data from 01/01/2010 to 30/06/2018 were used to conduct a retrospective comparative cohort analysis of BTA-naive patients with a BM diagnosis and preceding ST diagnosis. HCRU and treatment-related costs were compared in two matched cohorts of patients with and without a history of SREs, defined as pathological fracture, spinal cord compression, surgery to bone and radiation to bone. The first SRE was defined as the patient-individual index date. Conversely, for the non-SRE patients, index dates were assigned randomly. Results In total, 45.20% of 9,832 patients reported experiencing at least one SRE (n = 4444) while 54.80% experienced none (n = 5388); 2,434 pairs of SRE and non-SRE patients were finally matched (mean age: 70.87/71.07 years; females: 39.07%/38.58%). Between SRE and non-SRE cohorts, significant differences in the average number of hospitalization days per patient-year (35.80/30.80) and associated inpatient-care costs (14,199.27€/10,787.31€) were observed. The total cost ratio was 1.16 (p

Suggested Citation

  • Fränce Hardtstock & Zeki Kocaata & Thomas Wilke & Axel Dittmar & Marco Ghiani & Vasily Belozeroff & David J. Harrison & Ulf Maywald & Hans Tesch, 2021. "Healthcare resource utilization and associated cost of patients with bone metastases from solid tumors who are naïve to bone-targeting agents: a comparative analysis of patients with and without skele," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 22(2), pages 243-254, March.
    • Handle: RePEc:spr:eujhec:v:22:y:2021:i:2:d:10.1007_s10198-020-01247-z
    DOI: 10.1007/s10198-020-01247-z
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    References listed on IDEAS

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    1. Sarah Neubauer & Kristine Kreis & Mike Klora & Jan Zeidler, 2017. "Access, use, and challenges of claims data analyses in Germany," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 18(5), pages 533-536, June.
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    Blog mentions

    As found by EconAcademics.org, the blog aggregator for Economics research:
    1. Chris Sampson’s journal round-up for 22nd March 2021
      by Chris Sampson in The Academic Health Economists' Blog on 2021-03-22 12:00:01

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    More about this item

    Keywords

    Bone metastasis; Skeletal-related events; Healthcare resource utilization; Economic burden; Claims data; Bone-targeting agents;
    All these keywords.

    JEL classification:

    • I11 - Health, Education, and Welfare - - Health - - - Analysis of Health Care Markets

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