IDEAS home Printed from https://ideas.repec.org/a/spr/envsyd/v29y2009i2d10.1007_s10669-009-9227-3.html
   My bibliography  Save this article

Static magnetic field action on some markers of inflammation in animal model system—in vivo

Author

Listed:
  • L. Traikov

    (Medical University-Sofia)

  • K. Georgiev

    (Multi-profile Hospital for Active Treatment and Emergency Medicine)

  • A. Bocheva

    (Medical University-Sofia)

  • E. Dzambazova

    (Medical University-Sofia)

  • M. Markov

    (Buffalo Office)

Abstract

Experimentally induced acute inflammation in rats is a good model system which includes the complexity and dynamics of the processes; moreover there are many defined markers for following and estimating changes in an observed system. In this paper, we discuss an in vivo model of acute inflammation induced by carrageenan. Carrageenan-induced paw edema is a model of non-infectious acute inflammatory reaction to assess the contribution of mediators involved in vascular changes associated with acute inflammation and potential treatments. A complex approach into the investigation of possible effects of static magnetic fields (SMF) action on experimentally induced acute inflammation in rats (by measurements of the levels of specific stress markers) is very important in understanding the possible inflammatory mitigation effects, pain relief, and oxidative stress state of an organism. This approach could help for better understanding of the possible mechanisms of interaction of dynamic processes such as inflammation healing and pain relief with external SMF (25 mT at 10, 20 and 30 min exposure time). Results indicate that SMF with B = 25 mT for 30 min diminished the inflammatory process and decreased the levels of inflammatory markers (fibrinogen) and stress markers (ACTH, Cor) into the blood plasma in rats as when compared with sham exposed animals. The exact mechanism by which SMF contributes to the acceleration of inflammatory healing and decrease of inflammation markers in blood plasma in rats still remains unclear. We assume that two possible mechanisms exist. One is the direct interaction of SMF with free active oxygen forms (free radicals) affected by their membrane processes and related with the physiological functions. Another possible mechanism might be related to dynamic regulation of inflammation healing process.

Suggested Citation

  • L. Traikov & K. Georgiev & A. Bocheva & E. Dzambazova & M. Markov, 2009. "Static magnetic field action on some markers of inflammation in animal model system—in vivo," Environment Systems and Decisions, Springer, vol. 29(2), pages 225-231, June.
    • Handle: RePEc:spr:envsyd:v:29:y:2009:i:2:d:10.1007_s10669-009-9227-3
    DOI: 10.1007/s10669-009-9227-3
    as

    Download full text from publisher

    File URL: http://link.springer.com/10.1007/s10669-009-9227-3
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1007/s10669-009-9227-3?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:spr:envsyd:v:29:y:2009:i:2:d:10.1007_s10669-009-9227-3. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.springer.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.