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Drug-Gene Risk Stratification in Patients with Suspected Drug-Induced Interstitial Lung Disease

Author

Listed:
  • Marjolein Drent

    (Maastricht University
    St. Antonius Hospital
    ILD Care Foundation)

  • Petal A. Wijnen

    (St. Antonius Hospital
    ILD Care Foundation
    Maastricht University Medical Centre)

  • Naomi T. Jessurun

    (ILD Care Foundation
    Netherlands Pharmacovigilance Centre Lareb)

  • Ankie M. Harmsze

    (St. Antonius Hospital
    St. Antonius Hospital)

  • Otto Bekers

    (Maastricht University
    Maastricht University Medical Centre)

  • Aalt Bast

    (Maastricht University
    ILD Care Foundation)

Abstract

Background Pulmonary toxicity has been associated with drug use. This is often not recognized in clinical practice, and underestimated. Objective We aimed to establish whether polymorphisms in certain genes corresponding with a metabolic pathway of drug(s) used are associated with pulmonary toxicity in patients with suspected drug-induced interstitial lung disease (DI-ILD). Methods This retrospective observational study explored genetic variations in three clinically relevant cytochrome P450 (CYP) iso-enzymes (i.e., CYP2D6, CYP2C9, and CYP2C19) in a group of patients with a fibroticinterstitial lung disease, either non-specific interstitial pneumonia (n = 211) or idiopathic pulmonary fibrosis (n = 256), with a suspected drug-induced origin. Results Of the 467 patients, 79.0% showed one or more polymorphisms in the tested genes accompanied by the use of drug(s) metabolized by a corresponding affected metabolic pathway (60.0% poor metabolizers and/or using two or more drugs [likely DI-ILD], 37.5% using three or more [highly likely DI-ILD]). Most commonly used drugs were statins (63.1%) with a predominance among men (69.4 vs 47.1%, p

Suggested Citation

  • Marjolein Drent & Petal A. Wijnen & Naomi T. Jessurun & Ankie M. Harmsze & Otto Bekers & Aalt Bast, 2024. "Drug-Gene Risk Stratification in Patients with Suspected Drug-Induced Interstitial Lung Disease," Drug Safety, Springer, vol. 47(4), pages 355-363, April.
    • Handle: RePEc:spr:drugsa:v:47:y:2024:i:4:d:10.1007_s40264-024-01400-0
    DOI: 10.1007/s40264-024-01400-0
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