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Paracetamol Dosing Errors in People Aged 12 Years and Over: An Analysis of Over 14,000 Cases Reported to an Australian Poisons Information Centre

Author

Listed:
  • Annabelle S. Chidiac

    (The University of Sydney
    The Children’s Hospital at Westmead)

  • Nicholas A. Buckley

    (The University of Sydney
    The Children’s Hospital at Westmead)

  • Firouzeh Noghrehchi

    (The University of Sydney)

  • Rose Cairns

    (The University of Sydney
    The Children’s Hospital at Westmead)

Abstract

Introduction Paracetamol dosing errors can cause acute liver injury, with potentially toxic doses only slightly above the therapeutic range. This study aimed to characterise unintentional paracetamol overdose reported to an Australian poisons centre, including time trends, demographics, types of dosing errors, and outcomes. Methods Records regarding paracetamol dosing errors for individuals aged ≥12 years were extracted from the New South Wales Poisons Information Centre database, January 2017 to June 2023. Data from 2021 underwent an in-depth screening of free text case notes to examine: dose, duration, products involved, reasons for ingestion and outcomes including hospitalisation, treatment, liver transplantations and deaths. Where possible, complete outcome data were obtained from medical records of New South Wales hospitalised cases in 2021. Results There were 14,380 exposures due to paracetamol dosing errors (predominantly self-administered, median age 43 years, 62.6% female), with an average yearly increase of 2.5% (95% CI 1.6–3.8%; p

Suggested Citation

  • Annabelle S. Chidiac & Nicholas A. Buckley & Firouzeh Noghrehchi & Rose Cairns, 2024. "Paracetamol Dosing Errors in People Aged 12 Years and Over: An Analysis of Over 14,000 Cases Reported to an Australian Poisons Information Centre," Drug Safety, Springer, vol. 47(12), pages 1293-1306, December.
    • Handle: RePEc:spr:drugsa:v:47:y:2024:i:12:d:10.1007_s40264-024-01472-y
    DOI: 10.1007/s40264-024-01472-y
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