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Psoriasis After Exposure to Angiotensin-Converting Enzyme Inhibitors: French Pharmacovigilance Data and Review of the Literature

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Listed:
  • Brahim Azzouz

    (Reims University Hospital
    University of Reims Champagne-Ardenne)

  • Aurore Morel

    (Reims University Hospital)

  • Lukshe Kanagaratnam

    (University of Reims Champagne-Ardenne
    Reims University Hospital)

  • Emmanuelle Herlem

    (Reims University Hospital)

  • Thierry Trenque

    (Reims University Hospital
    University of Reims Champagne-Ardenne)

Abstract

Introduction Angiotensin-converting enzyme inhibitors (ACEIs) can induce or aggravate psoriasis. This risk is not specified in the Summary of Product Characteristics (SmPC) of some drugs of this class, such as captopril or enalapril. We aimed to investigate the association between psoriasis and ACEI exposure. Methods We analyzed spontaneous reports recorded in the French national Pharmacovigilance Database (FPVD) from 1985 to 31 December 2018. The association between psoriasis and ACEI exposure was assessed using the case/non-case method. We also reviewed literature reports. Results One hundred reports of psoriasis after ACEI exposure were registered in the FPVD. The reporting odds ratio (ROR) was 2.40 (95% CI 1.96–2.95). Time to onset was

Suggested Citation

  • Brahim Azzouz & Aurore Morel & Lukshe Kanagaratnam & Emmanuelle Herlem & Thierry Trenque, 2019. "Psoriasis After Exposure to Angiotensin-Converting Enzyme Inhibitors: French Pharmacovigilance Data and Review of the Literature," Drug Safety, Springer, vol. 42(12), pages 1507-1513, December.
    • Handle: RePEc:spr:drugsa:v:42:y:2019:i:12:d:10.1007_s40264-019-00865-8
    DOI: 10.1007/s40264-019-00865-8
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