IDEAS home Printed from https://ideas.repec.org/a/spr/drugsa/v41y2018i4d10.1007_s40264-017-0624-0.html
   My bibliography  Save this article

Mixed Approach Retrospective Analyses of Suicide and Suicidal Ideation for Brand Compared with Generic Central Nervous System Drugs

Author

Listed:
  • Ning Cheng

    (Auburn University)

  • Md. Motiur Rahman

    (Auburn University)

  • Yasser Alatawi

    (Auburn University)

  • Jingjing Qian

    (Auburn University)

  • Peggy L. Peissig

    (Biomedical Informatics Research Center, Marshfield Clinic Research Institute)

  • Richard L. Berg

    (Biomedical Informatics Research Center, Marshfield Clinic Research Institute)

  • C. David Page

    (University of Wisconsin
    University of Wisconsin)

  • Richard A. Hansen

    (Auburn University)

Abstract

Introduction Several different types of drugs acting on the central nervous system (CNS) have previously been associated with an increased risk of suicide and suicidal ideation (broadly referred to as suicide). However, a differential association between brand and generic CNS drugs and suicide has not been reported. Objectives This study compares suicide adverse event rates for brand versus generic CNS drugs using multiple sources of data. Methods Selected examples of CNS drugs (sertraline, gabapentin, zolpidem, and methylphenidate) were evaluated via the US FDA Adverse Event Reporting System (FAERS) for a hypothesis-generating study, and then via administrative claims and electronic health record (EHR) data for a more rigorous retrospective cohort study. Disproportionality analyses with reporting odds ratios and 95% confidence intervals (CIs) were used in the FAERS analyses to quantify the association between each drug and reported suicide. For the cohort studies, Cox proportional hazards models were used, controlling for demographic and clinical characteristics as well as the background risk of suicide in the insured population. Results The FAERS analyses found significantly lower suicide reporting rates for brands compared with generics for all four studied products (Breslow–Day P

Suggested Citation

  • Ning Cheng & Md. Motiur Rahman & Yasser Alatawi & Jingjing Qian & Peggy L. Peissig & Richard L. Berg & C. David Page & Richard A. Hansen, 2018. "Mixed Approach Retrospective Analyses of Suicide and Suicidal Ideation for Brand Compared with Generic Central Nervous System Drugs," Drug Safety, Springer, vol. 41(4), pages 363-376, April.
    • Handle: RePEc:spr:drugsa:v:41:y:2018:i:4:d:10.1007_s40264-017-0624-0
    DOI: 10.1007/s40264-017-0624-0
    as

    Download full text from publisher

    File URL: http://link.springer.com/10.1007/s40264-017-0624-0
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1007/s40264-017-0624-0?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    References listed on IDEAS

    as
    1. Geetha Iyer & Sathiya Priya Marimuthu & Jodi B. Segal & Sonal Singh, 2017. "An Algorithm to Identify Generic Drugs in the FDA Adverse Event Reporting System," Drug Safety, Springer, vol. 40(9), pages 799-808, September.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Richard A. Hansen & Ning Cheng & Md. Motiur Rahman & Yasser Alatawi & Jingjing Qian & Peggy L. Peissig & Richard L. Berg & C. David Page, 2018. "Authors' Reply to Courtney Suggs and Colleagues’ Comment on: “Mixed Approach Retrospective Analyses of Suicide and Suicidal Ideation for Brand Compared with Generic Central Nervous System Drugs”," Drug Safety, Springer, vol. 41(12), pages 1423-1424, December.
    2. Courtney M. Suggs & Robert L. Levin & Andrew D. Mosholder & Richard S. Swain & Liang Zhao, 2018. "Comment on: “Mixed Approach Retrospective Analyses of Suicide and Suicidal Ideation for Brand Compared with Generic Central Nervous System Drugs”," Drug Safety, Springer, vol. 41(12), pages 1419-1421, December.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Courtney M. Suggs & Robert L. Levin & Andrew D. Mosholder & Richard S. Swain & Liang Zhao, 2018. "Comment on: “Mixed Approach Retrospective Analyses of Suicide and Suicidal Ideation for Brand Compared with Generic Central Nervous System Drugs”," Drug Safety, Springer, vol. 41(12), pages 1419-1421, December.
    2. Sonal Singh, 2018. "The Safety of Generic Prescription Drugs in the United States," Drug Safety, Springer, vol. 41(4), pages 325-328, April.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:spr:drugsa:v:41:y:2018:i:4:d:10.1007_s40264-017-0624-0. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.springer.com/economics/journal/40264 .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.