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Antibiotic-Induced Liver Injury in Paediatric Outpatients: A Case-Control Study in Primary Care Databases

Author

Listed:
  • Carmen Ferrajolo

    (University of Campania
    Erasmus University Medical Centre)

  • Katia M. C. Verhamme

    (Erasmus University Medical Centre)

  • Gianluca Trifirò

    (Erasmus University Medical Centre
    University of Messina)

  • Geert W. ‘t Jong

    (Erasmus University Medical Centre
    University of Manitoba)

  • Gino Picelli

    (Pedianet-Società Servizi Telematici SRL)

  • Carlo Giaquinto

    (Pedianet-Società Servizi Telematici SRL
    University of Padua)

  • Giampiero Mazzaglia

    (Italian College of General Practitioners)

  • Bruno H. Stricker

    (Erasmus University Medical Centre)

  • Francesco Rossi

    (University of Campania)

  • Annalisa Capuano

    (University of Campania)

  • Miriam C. J. M. Sturkenboom

    (Erasmus University Medical Centre
    Erasmus University Medical Centre)

Abstract

Introduction Antibiotics are the most commonly prescribed drug class in children. Real-world data mining on the paediatric population showed potential associations between antibiotic use and acute liver injury. Objective We assessed risk estimates of liver injury associated with antibiotic use in children and adolescent outpatients. Methods A large, multi-database, population-based, case-control study was performed in people

Suggested Citation

  • Carmen Ferrajolo & Katia M. C. Verhamme & Gianluca Trifirò & Geert W. ‘t Jong & Gino Picelli & Carlo Giaquinto & Giampiero Mazzaglia & Bruno H. Stricker & Francesco Rossi & Annalisa Capuano & Miriam C, 2017. "Antibiotic-Induced Liver Injury in Paediatric Outpatients: A Case-Control Study in Primary Care Databases," Drug Safety, Springer, vol. 40(4), pages 305-315, April.
    • Handle: RePEc:spr:drugsa:v:40:y:2017:i:4:d:10.1007_s40264-016-0493-y
    DOI: 10.1007/s40264-016-0493-y
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    Cited by:

    1. Gianluca Trifirò & Rosa Gini & Francesco Barone-Adesi & Ettore Beghi & Anna Cantarutti & Annalisa Capuano & Carla Carnovale & Antonio Clavenna & Mirosa Dellagiovanna & Carmen Ferrajolo & Matteo Franch, 2019. "The Role of European Healthcare Databases for Post-Marketing Drug Effectiveness, Safety and Value Evaluation: Where Does Italy Stand?," Drug Safety, Springer, vol. 42(3), pages 347-363, March.
    2. Carmen Ferrajolo & Cristina Scavone & Monia Donati & Oscar Bortolami & Giovanna Stoppa & Domenico Motola & Alfredo Vannacci & Alessandro Mugelli & Roberto Leone & Annalisa Capuano, 2018. "Antidepressant-Induced Acute Liver Injury: A Case–Control Study in an Italian Inpatient Population," Drug Safety, Springer, vol. 41(1), pages 95-102, January.

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