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Effect of Medications for Gastric Acid-Related Symptoms on Total Motile Sperm Count and Concentration: A Case–Control Study in Men of Subfertile Couples from the Netherlands

Author

Listed:
  • Nicole A. Huijgen

    (Erasmus MC)

  • Hedwig J. Goijen

    (Erasmus MC)

  • John M. Twigt

    (Erasmus MC)

  • Annemarie G. M. G. J. Mulders

    (Erasmus MC)

  • Jan Lindemans

    (Erasmus MC)

  • Gert R. Dohle

    (Erasmus MC)

  • Joop S. E. Laven

    (Erasmus MC)

  • Régine P. M. Steegers-Theunissen

    (Erasmus MC
    Erasmus MC)

Abstract

Introduction Gastric acid-related symptoms are highly prevalent in the general population (21–40%), and more than 11% of individuals use medication for the treatment of these symptoms. The uptake of micronutrients is dependent on the gastrointestinal potential of hydrogen (pH). Objective We hypothesized that medication affecting gastrointestinal pH reduces the availability of B vitamins, thereby deranging one-carbon metabolism and detrimentally affecting spermatogenesis. Methods This explorative nested case–control study in men of subfertile couples investigated associations between medication used for gastric acid-related symptoms and semen parameters. We included 40 men using medication for gastric acid-related symptoms and 843 men not using medication. Semen analyses were performed between 70 days before and 21 days after the visit. Results The use of medication was associated with a twofold higher risk of a low total motile sperm count [TMSC

Suggested Citation

  • Nicole A. Huijgen & Hedwig J. Goijen & John M. Twigt & Annemarie G. M. G. J. Mulders & Jan Lindemans & Gert R. Dohle & Joop S. E. Laven & Régine P. M. Steegers-Theunissen, 2017. "Effect of Medications for Gastric Acid-Related Symptoms on Total Motile Sperm Count and Concentration: A Case–Control Study in Men of Subfertile Couples from the Netherlands," Drug Safety, Springer, vol. 40(3), pages 241-248, March.
    • Handle: RePEc:spr:drugsa:v:40:y:2017:i:3:d:10.1007_s40264-016-0488-8
    DOI: 10.1007/s40264-016-0488-8
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