IDEAS home Printed from https://ideas.repec.org/a/spr/drugsa/v39y2016i8d10.1007_s40264-016-0424-y.html
   My bibliography  Save this article

Age at First Rotavirus Vaccination and Risk of Intussusception in Infants: A Public Health Modeling Analysis

Author

Listed:
  • Chee Fu Yung

    (KK Women’s and Children’s Hospital)

  • Chia Yin Chong

    (KK Women’s and Children’s Hospital
    Duke-National University of Singapore Graduate Medical School
    National University of Singapore)

  • Koh Cheng Thoon

    (KK Women’s and Children’s Hospital
    Duke-National University of Singapore Graduate Medical School
    National University of Singapore)

Abstract

Introduction The epidemiology of naturally occurring intussusception is known to increase significantly between the ages of 3 and 8 months. Post-licensure studies have reported a fivefold and twofold increase in intussusception in the first week after the first dose and second dose, respectively, of current rotavirus vaccines (RVs). Purpose We carried out a public health risk analysis to model the impact of age at first vaccination in relation to rotavirus vaccination and risk of intussusception in infants. Method We created a static model for a birth cohort followed until 1 year old to estimate the number of excess intussusception hospitalizations which could be caused by three different infant rotavirus vaccination schedules. A relative risk of 5.45 in the first 7 days after the first dose and 1.75 in the first 7 days after the second dose was used in the model. Result We estimated that the risk of intussusception would be the lowest at about 1 in 49,000 if both first and second dose RVs were given at 3 months old. Conclusion Our epidemiological example illustrates the importance of ensuring that the first two doses of RVs are administered in infants

Suggested Citation

  • Chee Fu Yung & Chia Yin Chong & Koh Cheng Thoon, 2016. "Age at First Rotavirus Vaccination and Risk of Intussusception in Infants: A Public Health Modeling Analysis," Drug Safety, Springer, vol. 39(8), pages 745-748, August.
    • Handle: RePEc:spr:drugsa:v:39:y:2016:i:8:d:10.1007_s40264-016-0424-y
    DOI: 10.1007/s40264-016-0424-y
    as

    Download full text from publisher

    File URL: http://link.springer.com/10.1007/s40264-016-0424-y
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1007/s40264-016-0424-y?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Claire E Otero & Stephanie N Langel & Maria Blasi & Sallie R Permar, 2020. "Maternal antibody interference contributes to reduced rotavirus vaccine efficacy in developing countries," PLOS Pathogens, Public Library of Science, vol. 16(11), pages 1-10, November.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:spr:drugsa:v:39:y:2016:i:8:d:10.1007_s40264-016-0424-y. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.springer.com/economics/journal/40264 .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.