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Safety and Tolerability of Pharmacological Treatment of Alcohol Dependence: Comprehensive Review of Evidence

Author

Listed:
  • Julia M. A. Sinclair

    (University of Southampton
    Academic Centre, College Keep)

  • Sophia E. Chambers

    (University of Southampton)

  • Celia J. Shiles

    (University of Southampton
    Academic Foundation Programme, Wessex Deanery)

  • David S. Baldwin

    (University of Southampton
    University of Cape Town)

Abstract

Alcohol use disorders (AUD) cause significant morbidity and mortality worldwide, but pharmacological treatments for them are underused, despite evidence of efficacy. Acamprosate, naltrexone, nalmefene and disulfiram are all approved in one or more region for the treatment of AUD. Baclofen currently has a temporary indication in France. Safety considerations for using psychopharmacological treatments in this patient group include the impact of concurrent alcohol consumption at high levels; multiple physical comorbidities that may interfere with pharmacological effects, distribution and metabolism; and concomitant medication for the treatment of comorbid physical and psychiatric conditions. The five drugs, including an extended-release injectable suspension of naltrexone, have different safety profiles that need to be balanced with the treatment objective (initiation or continuation of abstinence, or reduction of drinking), individual patient preferences and comorbid conditions. Appropriate treatment will be based on the unique risk–benefit profile in each case.

Suggested Citation

  • Julia M. A. Sinclair & Sophia E. Chambers & Celia J. Shiles & David S. Baldwin, 2016. "Safety and Tolerability of Pharmacological Treatment of Alcohol Dependence: Comprehensive Review of Evidence," Drug Safety, Springer, vol. 39(7), pages 627-645, July.
    • Handle: RePEc:spr:drugsa:v:39:y:2016:i:7:d:10.1007_s40264-016-0416-y
    DOI: 10.1007/s40264-016-0416-y
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    Cited by:

    1. Claire Ronsley & Seonaid Nolan & Rod Knight & Kanna Hayashi & Jano Klimas & Alex Walley & Evan Wood & Nadia Fairbairn, 2020. "Treatment of stimulant use disorder: A systematic review of reviews," PLOS ONE, Public Library of Science, vol. 15(6), pages 1-22, June.

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