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Blocking policies in pharmaceutical transfer lines

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  • Esra Dogan-Sahiner
  • Tayfur Altiok

Abstract

In this study, we present cases from the pharmaceutical industry involving buffers and blocking. The industry has many dedicated production lines, aseptic transfer lines (production of injectables) and robotic cells (sample preparation in laboratories). In many cases, the lines are fast (500-1000 units/minute) and they are stopped entirely when a machine fails. Also, there are many lines having medium speed which are controlled by using circular, secondary (and dynamic in size at times) buffers. Good Manufacturing Practice (GMP) forces the industry to work with certain policies such as scrapping upon failure as well as stopping the immediate upstream machines while clearing the buffers. We will present analytical results for some of the above scenarios. Copyright Kluwer Academic Publishers 1998

Suggested Citation

  • Esra Dogan-Sahiner & Tayfur Altiok, 1998. "Blocking policies in pharmaceutical transfer lines," Annals of Operations Research, Springer, vol. 79(0), pages 323-347, January.
    • Handle: RePEc:spr:annopr:v:79:y:1998:i:0:p:323-347:10.1023/a:1018983024118
    DOI: 10.1023/A:1018983024118
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    Cited by:

    1. George Liberopoulos & George Kozanidis & Panagiotis Tsarouhas, 2007. "Performance Evaluation of an Automatic Transfer Line with WIP Scrapping During Long Failures," Manufacturing & Service Operations Management, INFORMS, vol. 9(1), pages 62-83, December.

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