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Designing a sustainable closed-loop pharmaceutical supply chain in a competitive market considering demand uncertainty, manufacturer’s brand and waste management

Author

Listed:
  • Zeinab Sazvar

    (University of Tehran)

  • Mahsa Zokaee

    (University of Tehran)

  • Reza Tavakkoli-Moghaddam

    (University of Tehran)

  • Samira Al-sadat Salari

    (University of Tehran)

  • Sina Nayeri

    (University of Tehran)

Abstract

Pharmaceutical supply chain (PSC) is one of the most important healthcare supply chains and the recent pandemic (COVID-19) has completely proved it. Also, the environmental and social impacts of PSCs are undeniable due to the daily entrance of a large amount of pharmaceutical waste into the environment. However, studies on closed-loop PSCs (CLPSC) are rarely considered real-world requirements such as competition among diverse brands of manufacturers, the dependency of customers’ demand on products’ price and quality, and diverse reverse flows of end-of-life medicines. In this study, a scenario-based Multi-Objective Mixed-Integer Linear Programming model is developed to design a sustainable CLPSC, which investigates the reverse flows of expired medicines as three classes (must be disposed of, can be remanufactured and can be recycled). To study the competitive market and deal with demand uncertainty, a novel scenario-based game theory model is proposed. The demand function for each brand depends on the price and quality provided. Then, a hybrid solution approach is provided by combining the LP-metrics method with a heuristic algorithm. Furthermore, a real case study is investigated to evaluate the application of the model. Finally, sensitivity analysis and managerial insights are provided. The numerical results show that the proposed classification of reverse flows leads to proper waste management, making money, and reducing both disposal costs and raw material usage. Moreover, competition increases PSCs performance and improves the supply of products to pharmacies.

Suggested Citation

  • Zeinab Sazvar & Mahsa Zokaee & Reza Tavakkoli-Moghaddam & Samira Al-sadat Salari & Sina Nayeri, 2022. "Designing a sustainable closed-loop pharmaceutical supply chain in a competitive market considering demand uncertainty, manufacturer’s brand and waste management," Annals of Operations Research, Springer, vol. 315(2), pages 2057-2088, August.
    • Handle: RePEc:spr:annopr:v:315:y:2022:i:2:d:10.1007_s10479-021-03961-0
    DOI: 10.1007/s10479-021-03961-0
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    References listed on IDEAS

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    1. Shiva Moslemi & Mohammad Hossein Zavvar Sabegh & Abolfazl Mirzazadeh & Yucel Ozturkoglu & Eric Maass, 2017. "A multi-objective model for multi-production and multi-echelon closed-loop pharmaceutical supply chain considering quality concepts: NSGAII approach," International Journal of System Assurance Engineering and Management, Springer;The Society for Reliability, Engineering Quality and Operations Management (SREQOM),India, and Division of Operation and Maintenance, Lulea University of Technology, Sweden, vol. 8(2), pages 1717-1733, November.
    2. Krumwiede, Dennis W. & Sheu, Chwen, 2002. "A model for reverse logistics entry by third-party providers," Omega, Elsevier, vol. 30(5), pages 325-333, October.
    3. E. Grigoroudis & E. Tsitsiridi & C. Zopounidis, 2013. "Linking customer satisfaction, employee appraisal, and business performance: an evaluation methodology in the banking sector," Annals of Operations Research, Springer, vol. 205(1), pages 5-27, May.
    4. Ali Timajchi & Seyed Mohammad Javad Mirzapour Al-E-Hashem & Yacine Rekik, 2019. "Inventory routing problem for hazardous and deteriorating items in the presence of accident risk with transshipment option," Post-Print hal-02312116, HAL.
    5. Weraikat, Dua & Zanjani, Masoumeh Kazemi & Lehoux, Nadia, 2016. "Two-echelon pharmaceutical reverse supply chain coordination with customers incentives," International Journal of Production Economics, Elsevier, vol. 176(C), pages 41-52.
    6. Anil Kumar & Edmundas Kazimieras Zavadskas & Sachin Kumar Mangla & Varun Agrawal & Kartik Sharma & Divyanshu Gupta, 2019. "When risks need attention: adoption of green supply chain initiatives in the pharmaceutical industry," International Journal of Production Research, Taylor & Francis Journals, vol. 57(11), pages 3554-3576, June.
    7. Vahdani, Behnam & Tavakkoli-Moghaddam, Reza & Modarres, Mohammad & Baboli, Armand, 2012. "Reliable design of a forward/reverse logistics network under uncertainty: A robust-M/M/c queuing model," Transportation Research Part E: Logistics and Transportation Review, Elsevier, vol. 48(6), pages 1152-1168.
    8. Timajchi, Ali & Mirzapour Al-e-Hashem, Seyed M.J. & Rekik, Yacine, 2019. "Inventory routing problem for hazardous and deteriorating items in the presence of accident risk with transshipment option," International Journal of Production Economics, Elsevier, vol. 209(C), pages 302-315.
    9. Haidar Abbas, 2018. "Barriers to reverse logistics practices in pharmaceutical supply chains: an ISM approach," International Journal of Business Excellence, Inderscience Enterprises Ltd, vol. 16(1), pages 47-60.
    10. Sazvar, Z. & Mirzapour Al-e-hashem, S.M.J. & Baboli, A. & Akbari Jokar, M.R., 2014. "A bi-objective stochastic programming model for a centralized green supply chain with deteriorating products," International Journal of Production Economics, Elsevier, vol. 150(C), pages 140-154.
    11. Chen, Xu & Yang, Huan & Wang, Xiaojun, 2019. "Effects of price cap regulation on the pharmaceutical supply chain," Journal of Business Research, Elsevier, vol. 97(C), pages 281-290.
    12. Zahiri, Behzad & Zhuang, Jun & Mohammadi, Mehrdad, 2017. "Toward an integrated sustainable-resilient supply chain: A pharmaceutical case study," Transportation Research Part E: Logistics and Transportation Review, Elsevier, vol. 103(C), pages 109-142.
    13. Wapee Manopiniwes & Takashi Irohara, 2017. "Stochastic optimisation model for integrated decisions on relief supply chains: preparedness for disaster response," International Journal of Production Research, Taylor & Francis Journals, vol. 55(4), pages 979-996, February.
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    1. Choudhury, Nishat Alam & Ramkumar, M. & Schoenherr, Tobias & Singh, Shalabh, 2023. "The role of operations and supply chain management during epidemics and pandemics: Potential and future research opportunities," Transportation Research Part E: Logistics and Transportation Review, Elsevier, vol. 175(C).

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