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Choice of Intensive Lifestyle Change and/or Metformin after Shared Decision Making for Diabetes Prevention: Results from the Prediabetes Informed Decisions and Education (PRIDE) Study

Author

Listed:
  • Tannaz Moin

    (David Geffen School of Medicine, University of California, Los Angeles, CA, USA
    VA Greater Los Angeles Health System and HSR&D Center for the Study of Healthcare Innovation, Implementation & Policy, Los Angeles, CA, USA)

  • Jacqueline M. Martin

    (Johns Hopkins University, Baltimore, MD, USA)

  • Carol M. Mangione

    (David Geffen School of Medicine, University of California, Los Angeles, CA, USA
    UCLA Fielding School of Public Health, Los Angeles, CA)

  • Jonathan Grotts

    (David Geffen School of Medicine, University of California, Los Angeles, CA, USA)

  • Norman Turk

    (David Geffen School of Medicine, University of California, Los Angeles, CA, USA)

  • Keith C. Norris

    (David Geffen School of Medicine, University of California, Los Angeles, CA, USA)

  • Chi-Hong Tseng

    (David Geffen School of Medicine, University of California, Los Angeles, CA, USA)

  • Kia Skrine Jeffers

    (David Geffen School of Medicine, University of California, Los Angeles, CA, USA)

  • Yelba Castellon-Lopez

    (David Geffen School of Medicine, University of California, Los Angeles, CA, USA)

  • Dominick L. Frosch

    (Palo Alto Medical Foundation for Health Care, Research and Education, Palo Alto, CA, USA)

  • O. Kenrik Duru

    (David Geffen School of Medicine, University of California, Los Angeles, CA, USA)

Abstract

Introduction While the Diabetes Prevention Program Study demonstrated that intensive lifestyle change and metformin both reduce type 2 diabetes incidence, there are little data on patient preferences in real-world, clinical settings. Methods The Prediabetes Informed Decisions and Education (PRIDE) study was a cluster-randomized trial of shared decision making (SDM) for diabetes prevention. In PRIDE, pharmacists engaged patients with prediabetes in SDM using a decision aid with information about both evidence-based options. We recorded which diabetes prevention option(s) participants chose after the SDM visit. We also evaluated logistic regression models examining predictors of choosing intensive lifestyle change ± metformin, compared to metformin or usual care, and predictors of choosing metformin ± intensive lifestyle change, compared to intensive lifestyle change or usual care. Results Among PRIDE participants ( n = 515), 55% chose intensive lifestyle change, 8.5% chose metformin, 15% chose both options, and 21.6% declined both options. Women (odds ratio [OR] = 1.60, P = 0.023) had higher odds than men of choosing intensive lifestyle change. Patients >60 years old (OR = 0.50, P = 0.028) had lower odds than patients

Suggested Citation

  • Tannaz Moin & Jacqueline M. Martin & Carol M. Mangione & Jonathan Grotts & Norman Turk & Keith C. Norris & Chi-Hong Tseng & Kia Skrine Jeffers & Yelba Castellon-Lopez & Dominick L. Frosch & O. Kenrik , 2021. "Choice of Intensive Lifestyle Change and/or Metformin after Shared Decision Making for Diabetes Prevention: Results from the Prediabetes Informed Decisions and Education (PRIDE) Study," Medical Decision Making, , vol. 41(5), pages 607-613, July.
    • Handle: RePEc:sae:medema:v:41:y:2021:i:5:p:607-613
    DOI: 10.1177/0272989X211001279
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