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Can Life Expectancy and QALYs Be Improved by a Framework for Deciding Whether to Apply Clinical Guidelines to Patients With Severe Comorbid Disease?

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  • R. Scott Braithwaite

Abstract

Background: Guidelines with short-term harms and long-term benefits are often applied to chronically ill patients who may not benefit. The payoff time framework has been proposed (i.e., do not apply a guideline if a patient’s life expectancy (LE) is shorter than when a guideline’s cumulative incremental benefits first exceed its cumulative incremental harms), but its health impact is unclear. Objective: To investigate whether the payoff time framework improves LE and/or quality-adjusted life-years (QALY) for chronically ill patients. Methods: I evaluate impact of the payoff time framework on LE and QALYs, assuming (1) high and constant background mortality rate from chronic illness (≥ 10% per year), (2) immediate guideline-related harm with probability 0.15 per year (corresponding to LE 0.11 per year (corresponding to LE

Suggested Citation

  • R. Scott Braithwaite, 2011. "Can Life Expectancy and QALYs Be Improved by a Framework for Deciding Whether to Apply Clinical Guidelines to Patients With Severe Comorbid Disease?," Medical Decision Making, , vol. 31(4), pages 582-595, July.
  • Handle: RePEc:sae:medema:v:31:y:2011:i:4:p:582-595
    DOI: 10.1177/0272989X10386117
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