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Prevalence of Antibodies Associated with Herd Immunity: A New Indicator to Evaluate the Establishment of Herd Immunity and to Decide Immunization Strategies

Author

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  • Pedro Plans

    (Health Department of Catalonia, General Directorate of Public Health, Barcelona, Spain, pedro.plans@gencat.net)

Abstract

Objective. To develop a method to estimate the critical prevalence of antibodies associated with herd immunity (p c ) and to assess the establishment of herd immunity against measles, mumps, rubella, varicella, and pertussis in Catalonia (Spain) using this method. Methods. The herd immunity is established when the prevalence of antibodies (positive serological results) is higher than p c = I c Se/PV, where I c is the prevalence of protected individuals necessary to block the transmission of an infection in the population, Se is the sensitivity of the serological test, and PV is the predictive value of a positive serological result. The establishment of herd immunity was assessed comparing the age-group specific p c with the prevalence of antibodies (p) observed in Catalonia in 2002 in schoolchildren (6—9 years) and individuals aged 14 to 29 years and 45 to 54 years. Results. The herd immunity was not established (p

Suggested Citation

  • Pedro Plans, 2010. "Prevalence of Antibodies Associated with Herd Immunity: A New Indicator to Evaluate the Establishment of Herd Immunity and to Decide Immunization Strategies," Medical Decision Making, , vol. 30(4), pages 438-443, July.
  • Handle: RePEc:sae:medema:v:30:y:2010:i:4:p:438-443
    DOI: 10.1177/0272989X09353453
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    Cited by:

    1. Masaya M. Saito & Keisuke Ejima & Ryo Kinoshita & Hiroshi Nishiura, 2018. "Assessing the Effectiveness and Cost-Benefit of Test-and-Vaccinate Policy for Supplementary Vaccination against Rubella with Limited Doses," IJERPH, MDPI, vol. 15(4), pages 1-12, March.

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