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Influence of the Way Results Are Presented on Research Interpretation and Medical Decision Making: The PRIMER Collaboration Randomized Studies

Author

Listed:
  • Thomas Philip Shakespeare

    (North Coast Cancer Institute, Coffs Harbour Health Campus, New South Wales, Australia, thomasshakespeare@gmail.com., PRIMER Collaboration, New South Wales, Australia)

  • Val Gebski

    (PRIMER Collaboration, New South Wales, Australia, National Health and Medical Council Clinical Trials Centre, University of Sydney, New South Wales, Australia)

  • Johann Tang

    (Radiotherapy Centre, The Cancer Institute, National University Hospital, Singapore)

  • Keith Lim

    (Radiotherapy Centre, The Cancer Institute, National University Hospital, Singapore)

  • Jiade Jay Lu

    (PRIMER Collaboration, New South Wales, Australia, Radiotherapy Centre, The Cancer Institute, National University Hospital, Singapore)

  • Xiaojian Zhang

    (PRIMER Collaboration, New South Wales, Australia, Shanghai Tumour Hospital, Shanghai, China)

  • Guoliang Jiang

    (Shanghai Tumour Hospital, Shanghai, China)

Abstract

Background. The manner of presentation of research results may affect how clinicians interpret research and make clinical decisions. The authors evaluate whether the use of confidence levels improve research interpretation and decision making compared with P values and 95% confidence intervals. Methods. The 2 Presentation and Interpretation of Medical Research (PRIMER) studies were 3-arm randomized trials. PRIMER 1 presented results of 5 fictitious scenarios with P values (P), P plus 95% confidence intervals (P + CI), or P, CI, and confidence levels (P + CI + CL); PRIMER 2 compared P + CI + CL, P + CI, and P + CL. Clinicians were asked to identify the correct interpretation of scenarios in terms of statistical and clinical significance and then indicate the intended decision making in terms of treatment recommendation. Results. Seventy-five and 246 clinicians participated in PRIMER 1 and PRIMER 2, respectively. In PRIMER 1, P+CI+CL was superior to P + CI and P (P

Suggested Citation

  • Thomas Philip Shakespeare & Val Gebski & Johann Tang & Keith Lim & Jiade Jay Lu & Xiaojian Zhang & Guoliang Jiang, 2008. "Influence of the Way Results Are Presented on Research Interpretation and Medical Decision Making: The PRIMER Collaboration Randomized Studies," Medical Decision Making, , vol. 28(1), pages 127-137, January.
    • Handle: RePEc:sae:medema:v:28:y:2008:i:1:p:127-137
    DOI: 10.1177/0272989X07309640
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