IDEAS home Printed from https://ideas.repec.org/a/sae/medema/v22y2002i5p386-393.html
   My bibliography  Save this article

Survival Impact of Tamoxifen Use for Breast Cancer Risk Reduction: Projections from a Patient-Specific Markov Model

Author

Listed:
  • Nananda F. Col

    (Decision Systems Group and Division of General Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts)

  • Robert J. Goldberg

    (University of Massachusetts Medical Center, Worcester, Massachusetts)

  • Richard K. Orr

    (Department of Medical Education, Spartanburg Regional Medical Center, Spartanburg, South Carolina)

  • John K. Erban

    (New England Medical Center, Boston, Massachusetts)

  • Jennifer M. Fortin

    (Decision Systems Group and Division of General Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts)

  • Rowan T. Chlebowski

    (Harbor-UCLA Research and Education Institute, Torrance, California)

Abstract

The authors estimate tamoxifen’s impact on life expectancy among healthy women. A Markov model compared the effects of 5 years of tamoxifen on survival among 50-year-old postmenopausal women. Scenarios were explored using alternative assumptions with regard to tamoxifen’s long-term effects on breast and endometrial cancer. Postmenopausal women without a uterus had substantial life expectancy gains from tamoxifen (1 to 4 months), whereas women with a uterus had such gains only if they were at a very high breast cancer risk. If tamoxifen’s impact on endometrial cancer persists after treatment is discontinued, women at high risk for endometrial cancer have life expectancy losses from tamoxifen unless they are at a very high risk for breast cancer. The authors conclude that tamoxifen use among postmenopausal women is associated with substantial life expectancy gains. However, this benefit is modulated in women at increased endometrial cancer risk and depends on assumptions concerning tamoxifen’s lingering effects on breast and endometrial cancer.

Suggested Citation

  • Nananda F. Col & Robert J. Goldberg & Richard K. Orr & John K. Erban & Jennifer M. Fortin & Rowan T. Chlebowski, 2002. "Survival Impact of Tamoxifen Use for Breast Cancer Risk Reduction: Projections from a Patient-Specific Markov Model," Medical Decision Making, , vol. 22(5), pages 386-393, October.
    • Handle: RePEc:sae:medema:v:22:y:2002:i:5:p:386-393
    DOI: 10.1177/027298902236942
    as

    Download full text from publisher

    File URL: https://journals.sagepub.com/doi/10.1177/027298902236942
    Download Restriction: no
    File URL: https://libkey.io/10.1177/027298902236942?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Gordon B. Hazen & Min Huang, 2006. "Parametric Sensitivity Analysis Using Large-Sample Approximate Bayesian Posterior Distributions," Decision Analysis, INFORMS, vol. 3(4), pages 208-219, December.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:sae:medema:v:22:y:2002:i:5:p:386-393. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: SAGE Publications (email available below). General contact details of provider: .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.