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Stability of Patients’ Preferences for Chemotherapy

Author

Listed:
  • Sylvia J. T. Jansen

    (Department of Clinical Oncology, Department of Medical Decision Making, Leiden University Medical Center, Leiden, the Netherlands)

  • Job Kievit

    (Department of Medical Decision Making, Leiden University Medical Center, Leiden, the Netherlands)

  • Marianne A. Nooij

    (Department of Clinical Oncology, Leiden University Medical Center, Leiden, the Netherlands)

  • Anne M. Stiggelbout

    (Department of Medical Decision Making, Leiden University Medical Center, Leiden, the Netherlands)

Abstract

Background. Studies have shown that utilities for a particular treatment, elicited by means of a hypothetical treatment scenario, may remain stable within the same patients when examined before, during, and after experiencing that treatment (within-group stability). However, other studies have found that utilities for a particular health state may differ between patient groups who are and who are not experiencing the particular health state (between-group differences). Objective. The authors evaluated this apparent contradiction in the case of adjuvant chemotherapy for breast cancer. A related purpose was to examine whether a chemotherapy scenario adequately reflects the patients’ own experiences with chemotherapy. Method. Forty-three patients with early-stage breast cancer evaluated their actually experienced health state and a chemotherapy scenario before, during, and after undergoing adjuvant chemotherapy (chemotherapy group). A control group of 51 patients for whom chemotherapy was not part of the treatment plan was interviewed at similar points in time. Utilities were elicited by means of a visual analog scale (VAS), a chained time trade-off (TTO), and a chained standard gamble (SG). Results. The utilities for the chemotherapy scenario remained relatively stable over time in the 2 patient groups. Furthermore, the chemotherapy scenario was evaluated more positively by patients in the chemotherapy group than by control patients (e.g., utilities before chemotherapy: VAS 0.69 vs. 0.50, TTO 0.88 vs.0.50, SG 0.92 vs. 0.58, all Ps

Suggested Citation

  • Sylvia J. T. Jansen & Job Kievit & Marianne A. Nooij & Anne M. Stiggelbout, 2001. "Stability of Patients’ Preferences for Chemotherapy," Medical Decision Making, , vol. 21(4), pages 295-306, August.
    • Handle: RePEc:sae:medema:v:21:y:2001:i:4:p:295-306
    DOI: 10.1177/0272989X0102100405
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    Cited by:

    1. Jiryoun Gong & Juhee Han & Donghwan Lee & Seungjin Bae, 2020. "A Meta-Regression Analysis of Utility Weights for Breast Cancer: The Power of Patients’ Experience," IJERPH, MDPI, vol. 17(24), pages 1-16, December.

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