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The Exclusion of Women from Clinical Trials of Thrombolytic Therapy

Author

Listed:
  • Charles Maynard
  • Harry P. Selker
  • Joni R. Beshansky
  • John L. Griffith
  • Christopher H. Schmid
  • Robert M. Califf
  • Ralph B. D'Agostino
  • Michael M. Laks
  • Kerry L. Lee
  • Galen S. Wagner
  • W. Douglas Weaver

Abstract

The thrombolytic predictive instrument (TPI) was developed to identify those patients most likely to benefit from thrombolytic therapy for acute myocardial infarction as well as to facilitate the earliest possible administration of this treatment. The TPI consists of predictive models derived from clinical data obtained from both clinical trials and data registries. These models are subject to potential bias due to combinations of primary data from different sources. The purpose of this investigation was to assess the influence of gender in developing the TPI database. In this database, there were 1,096 (22%) women and 3,826 (78%) men; only 38% of the women were enrolled in clinical trials, whereas 46% of the men were (p

Suggested Citation

  • Charles Maynard & Harry P. Selker & Joni R. Beshansky & John L. Griffith & Christopher H. Schmid & Robert M. Califf & Ralph B. D'Agostino & Michael M. Laks & Kerry L. Lee & Galen S. Wagner & W. Dougla, 1995. "The Exclusion of Women from Clinical Trials of Thrombolytic Therapy," Medical Decision Making, , vol. 15(1), pages 38-43, February.
    • Handle: RePEc:sae:medema:v:15:y:1995:i:1:p:38-43
    DOI: 10.1177/0272989X9501500107
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